Publication

[Scientific Reports] Researchers demonstrated that menstrual stromal cells-derived planar presenilin 1 (PSEN 1) I416T cholinergic-like cells and cerebral spheroids reproduced the typical neuropathological markers of familial Alzheimer’s disease in 4 post-transdifferentiating or 11 days of transdifferentiating, respectively.

[Scientific Reports] Scientists tested whether astrocytes-neuron lactate shuttle activation could be another potential underpinning mechanism that complements collateral flow in the protection process.

[Gut] Investigators determined IL-3 expression in samples from patients with inflammatory bowel disease and studied the impact of Il3 or Il3r deficiency on T cell-dependent experimental colitis.

[Nature Cancer] Researchers showed that both wild-type and interleukin-2 receptor-β/interleukin-2 receptor-γ (IL-2Rβγ)-attenuated agonists that preserved IL-2Rα activities could effectively expand tumor-specific CD8+ T cells.

[Nature Communications] Scientists described CAR T cells targeting tumor-associated glycoprotein-72, utilizing the CD28 transmembrane domain upstream of the 4-1BB co-stimulatory domain as a driver of potent anti-tumor activity and interferon gamma secretion.

[Nature Communications] The authors measured the immune cell transcriptional profile of paired lower esophageal sphincter tissue and blood samples in achalasia and controls using single-cell RNA sequencing.