Publication

[Stem Cells and Development] Parallel genome-wide CRISPR/Cas9 knockout screens were applied in ESCs cultured in the serum plus LIF and in the 2i plus LIF conditions.The candidate genes were classified into seven groups based on their positive or negative effects on self-renewal.

[Immunity] Using in-depth integrated multi-omics, researchers dissected the host response dynamics during multiple disease phases to reveal the molecular and cellular landscapes in the blood.

[Science Immunology] Investigators compared the efficacy of three booster vaccines against Omicron BA.5 challenge in rhesus macaques: mRNA-1273, the Novavax ancestral spike protein vaccine, or Omicron BA.1 spike protein version.

[Nature Communications] Researchers tracked SARS-CoV-2 receptor binding domain-specific antibody responses up to six months following Omicron BA.1 breakthrough infection in six mRNA-vaccinated individuals.

[Communications Biology] Using a computational design strategy, investigators designed an affinity-enhanced ACE2 decoy, FLIF, that exhibited tight binding to SARS-CoV-2 delta and omicron variants, and experimental findings suggested that moving forward, affinity-enhanced ACE2 decoys like FLIF may be required to combat evolving SARS-CoV-2 variants.

[Structure] Structural analysis of these monoclonal antibodies (mAbs) in complex with trimeric spike protein showed that all three mAbs bivalently bind spike with two mAbs targeting class 1 and one targeting a class 4 receptor binding domain epitope.