Publication

[iScience] Investigators reported that zinc finger homeobox 2 (Zhx2) orchestrated β cell mass and function by regulating paired box protein pax-6 (Pax6).

[Journal of Endocrinology] Researchers elucidated the β-cell protective effect of VGF nerve growth factor inducible (VGF) on a streptozotocin-induced diabetic model using VGF-overexpressing mice and also examined the therapeutic effect by a small molecule, SUN N8075 which is an inducer of VGF.

[Science] To investigate the origins and impact of epigenetic plasticity during early neoplasia, the authors performed single-cell analyses on normal, inflamed, premalignant, and malignant tissues in autochthonous models of pancreatic cancer.

[Cell Death & Differentiation] Scientists dentified SUMO-specific protease 3 (SENP3) as a potential suppressor of PDAC progression through an in vivo metastatic model. Further studies revealed that SENP3 inhibited PDAC invasion in a SUMO system dependent fashion.

[Molecular Oncology] Investigators reported that ezrin expression in PDAC cell-derived small extracellular vesicles could activate fibroblasts, resulting in increased migration ability and high expression of α-SMA, PDGFRB, and high production of extracellular matrix in fibroblasts.

[Cellular Oncology] The authors demonstrated that METTL3, the key regulator of N6-methyladenosine modification, was downregulated in PDAC, and negatively correlated with PDAC malignant features.