Publication

[Molecular Psychiatry] The authors reported a point mutation on SHANK2, which was found in a patient with autism. This mutation resulted in an early stop codon and an aberrant splicing event that impacted SHANK2 transcript variants distinctly. iPSCs carrying this mutation failed to differentiate into functional dopamine neurons.

[Cell Death Discovery] Researchers analyzed the prognostic value and clinical significance of serpin family a member 1 (SERPINA1) in colorectal cancer, and predicted potential transcription factors.

[Cancer Research] Scientists investigated the vascular microenvironment of PDAC by applying imaging mass cytometry using a 26-antibody panel on 35 regions of interest across nine patients, capturing over 140,000 single cells.

[Schizophrenia] Scientists aimed to discover transcriptomic differences between inflammatory subgroups of schizophrenia in the subependymal zone (SEZ). Total RNA sequencing was performed on SEZ tissue from schizophrenia cases, designated into low inflammation and high inflammation subgroups, based on cluster analysis of inflammation marker gene expression.

[Scientific Reports] Researchers adopted a multimodal approach, combining the local mechanical stimulation with variations of culture substrate stiffness. They found that primary rat cardiac fibroblasts cultured on stiff substrates showed a broad Piezo1 distribution in the cell with particular accumulation at the mitochondria membrane.

[BMC Molecular And Cell Biology] Investigators assessed the multifaceted interactions between palmitic acid, cell proliferation, and the intestinal epithelial barrier using a canine colonoid model. Canine models, due to their relevance in simulating human intestinal diseases, offer a unique platform to explore the molecular mechanisms underlying high-fat diet-derived intestinal dysfunction.