Publication

[Haematologica] The C-terminal GATA1 undergoes frameshifting translation as a consequence of this double-base deletion mutation.To investigate the specific function and pathogenic mechanism of this mutant, in vitro mutant models of stable re-expression cells were generated.

[Cell Reports Medicine] Using single-cell transcriptomic and spatial multiplex immunofluorescence analyses, scientists showed that PD-L1+ tumor-associated macrophages were mature and immunostimulatory with spatial preference to T cells.

[Science] Investigators evaluated the effect of human leukocyte antigen heterozygosity on lung cancer risk, leveraging genetic and longitudinal clinical data from the UK Biobank and FinnGen together with multimodal genomic analyses of nonmalignant and lung tumor samples.

[Aging Cell] Investigators demonstrated for the first time the distinct role of primary aging and chronic inflammation/physical inactivity – the most important drivers of secondary aging, in the regulation of transcriptomic and proteomic profiles in human skeletal muscle.

[JCI Insight] Eight overweight but otherwise healthy sedentary adults were studied before and 14, 28, and 56 days after initiating atorvastatin therapy.

[Skeletal Muscle] By combining 3D-TESM and shRNA technologies, researchers developed a disease modelling strategy to induce distinct genetic deficiencies in a single human induced pluripotent stem cell-derived myogenic progenitor cell line within one week.