Publication

[Scientific Reports] Researchers demonstrate that the primed pluripotent state can generate trophoblast stem cells by activating pathways such as Epidermal Growth Factor and Wingless-related integration site, and by suppressing tumor growth factor beta, histone deacetylases, and Rho-associated protein kinase signaling pathways, all without the addition of exogenous Bone morphogenetic protein 4.

[Journal Of Virology] Scientists compared the susceptibility of neonatal human dermal fibroblast cells and human hiPSCs derived from neonatal human dermal fibroblast cells, which were genetically identical to human cytomegalovirus, using immunostaining, microarray, in situ hybridization, quantitative PCR, and scanning electron microscopy.

[Biochimica Et Biophysica Acta-Molecular Cell Research] The authors used multi-omics analyses to identify and characterize stemness genes, and focused on the zinc finger protein 982 that regulated stemness through the expression of Nanog, Zfp42, and Dppa3 in mouse ESCs.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors interrogated the role of DNA methylation, an environmentally malleable epigenetic mechanism, in orofacial development. Expression of the key DNA methyltransferase enzyme DNMT1 was detected throughout palate morphogenesis in the epithelium and underlying cranial neural crest cell mesenchyme, a highly proliferative multipotent stem cell population that forms orofacial connective tissue.

[Science Immunology] The authors identified candidate transcription factors associated with the atypical B cells population based on a human tonsillar B cell single cell dataset.

[npj Viruses] The effect of different COVID-19 booster strategies on SARS-CoV-2-specific T-cell responses was assessed in KTRs who showed a poor serological response after the first two mRNA-based primary vaccination doses.