Publication

[Journal of Endocrinological Investigation] Researchers identified distinct Th-like regulatory T cell (Treg) subsets in the peripheral blood of individuals with type 1 diabetes and investigated potential factors that affect Treg polarization within the context of autoimmunity.

[Journal For Immunotherapy of Cancer] Suppression of beta-1,4-galactosyltransferase 2 (B4GALT2) was found to enhance CD8+ T lymphocyte populations and their functional status, thereby potentiating anti-programmed cell death protein 1 immunotherapeutic efficacy in animal studies.

[Cell Death Discovery] Scientists demonstrated that Macrocarpal I was a potent inducer of immunogenic cell death by activating the PERK/eIF2A/ATF4/CHOP signaling pathway.

[ACS Nano ] Investigators demonstrated that the cytotoxic effects of the biotin receptor-targeting PtIV prodrug and increased oxygen levels synergistically reversed the tumor immune microenvironment, leading to improved antitumor efficacy.

[Nature] Scientists isolated stem cells and progenitors from young and old mice, identifying 221,890 somatic mutations genome-wide in 1,845 single-cell-derived colonies.

[JCI Insight] Scientists demonstrate that human umbilical cord MSC transplantation relieved early-onset depression-like behavior in both genetic lupus-prone and pristane-induced lupus mice by rescuing impaired hippocampal synaptic connectivity.