Publication

[Cancer Research] Researchers assessed the response to pharmacological inhibition of KRAS, the central oncogenic driver of PDAC. In a panel of PDAC cell lines, inhibition of KRASG12D with MRTX1133 yielded variable efficacy in suppressing cell growth and downstream gene expression programs in 2D cultures.

[Cancer Research] Investigators observed that cytidine deaminase was overexpressed in pancreatic adenocarcinoma from patients at baseline and was essential for experimental tumor growth.

[Nucleic Acids Research] Scientists reported the identification of 39 Hammerhead-variant ribozyme sequences in SARS-CoV-2. These sequences are highly conserved within SARS-CoV-2 variants but showed large diversity among other coronaviruses.

[Blood] Researchers demonstrated that patient mobilized stem cell grafts include high numbers of both effector CD8 T cells and immunosuppressive regulatory T cells.

[EMBO Reports] Using mass spectrometry-based interactomics methods, affinity purification-mass spectrometry and proximity-dependent biotin labeling, and chromatin immunoprecipitation sequencing we derive the comprehensive regulatory networks of these preimplantation transcription factors.

[Journal Of Cancer Research And Clinical Oncology] Scientists found that propranolol significantly reduced lung metastasis in 4T1 murine breast cancer cells. In vitro and in vivo experiments demonstrated that propranolol inhibited the epithelial–mesenchymal transition as evidenced by Western Blot analysis.