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Blinatumomab for First-Line Treatment of Children and Young Persons with B-ALL

[Journal Of Clinical Oncology] Data were collected for consecutive children and young persons aged 1-24 years with Philadelphia chromosome–positive or Philadelphia chromosome–negative B-ALL who received blinatumomab as first-line therapy.

E3 Ligase Trim35 Inhibits LSD1 Demethylase Activity through K63-Linked Ubiquitination and Enhances Anti-Tumor Immunity in NSCLC

[Cell Reports] Combinational use of a lysine-specific histone demethylase 1A (LSD1) inhibitor and anti-PD-1 therapy could significantly eradicate poorly immunogenic lung cancer with low Trim35.

IL-17A Promotes Tumorigenesis and Upregulates PD-L1 Expression in Non-Small Cell Lung Cancer

[Journal Of Translational Medicine] The function of interleukin-17A (IL-17A) was examined in vitro by wound healing, migration, invasion, plate colony formation, and T cell killing assay.

Age-Associated H3K9me2 Loss Alters the Regenerative Equilibrium between Murine Lung Alveolar and Bronchiolar Progenitors

[Developmental Cell] Investigators reported that histone H3 lysine 9 di-methylation (H3K9me2), mediated by the methyltransferase G9a, regulated the dynamics of distal lung epithelial progenitor cells and that this regulation deteriorated with age.

Epigenetic Reprogramming Drives Epithelial Disruption in COPD

[American Journal Of Respiratory Cell And Molecular Biology] Scientists sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin disrupted epithelial integrity, and if by reducing these epigenetic marks, they could restore epithelial integrity and rescue alveolar airspace destruction.

Effect of Delayed Cord Clamping on Cerebral Hemodynamics in Preterm Infants

[Heliyon] Neonatologists selected preterm infants eligible for inclusion and exclusion, and divided them into delayed cord clamping group and immediate cord clamping group according to the way of umbilical cord ligation performed by obstetrics department, and matched them 1:1 according to gestational age.

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