Publication

[Nano Letters] Researchers successfully engineered CD4+ T cells into Foxp3-T cells that transiently exhibited an immunosuppressive phenotype and functionally suppressed the proliferation of effector T cells

[Nature] Investigators uncovered an inflammatory loop between tumour cells and interleukin-1β-expressing tumor-associated macrophages, a subset of macrophages elicited by a local synergy between prostaglandin E2, and tumor necrosis factor.

[Experimental & Molecular Medicine] Scientists found that MΦ-C4 exhibited relatively low expression of both M1 and M2 signature genes, loss of inflammatory pathways and antigen presentation, instead demonstrating enhanced signaling for proliferation, mitochondrial functions, and metabolism.

[Cell Stem Cell] The authors described that pluripotent stem cell-derived human colonic organoids co-developped a diverse population of immune cells, including those that undergo stereotypical steps in differentiation, resulting in the generation of functional macrophages.

[Cell] Anti-NMDA receptor (NMDAR)-specific chimeric autoantibody receptor T cells recognized a large panel of human patient-derived autoantibodies, released effector molecules, proliferated, and selectively killed antigen-specific target cell lines even in the presence of high autoantibody concentrations.

[Science Signaling] Knocking out Dok3 enhanced the production of the cytokine IFN-γ by T cells, which conferred protection against experimental atopic dermatitis–like skin inflammation in mice.