Publication

[APL Bioengineering] Investigators performed analyses of whole-transcriptome microarray data from mouse vascular smooth muscle cells (VSMCs) cultured on stiff hydrogels simulating arterial pathology that identified 623 genes that were significantly and differentially expressed relative to expression in VSMCs cultured on soft hydrogels.

[Haematologica] Mutational profiling of myelodysplastic syndromes (MDS) samples identified ASXL1 mutations as predictors of response. Further, increased response rates were associated with higher gene-expression of the pro-apoptotic factor NOXA in ASXL1 mutated samples.

[Nature Communications] The authors described an integrated neurodegeneration checkpoint response to early pathological changes that restricted further disease progression and preserves cognitive function.

[Nature Neuroscience] Researchers found that suppressing the firing of cerebellar Purkinje cells rapidly excited forebrain areas that contributed to functions such as emotional regulation and motor functions but that the classic cerebellar outputs, the deep cerebellar nuclei, did not directly project there.

[npj Precision Oncology] Combining high-mass-resolution imaging mass spectrometry with consensus clustering, four tumor- and four stroma-specific subtypes with distinct metabolite patterns were identified in 330 lung squamous cell carcinoma patients.

[Cell Death Discovery] Scientists found that in lung cancer cells, the expression of CNOT3 could be regulated by epidermal growth factor receptor (EGFR) signaling pathway and c-Jun transcriptionally regulated its expression.