Publication

[Communications Biology] Researchers systematically investigated the neutral lipid–synthesizing enzymes diacylglycerol O-acyltransferases and the sterol O-acyltransferase 1 in orthoflavivirus infection.

[NPJ Viruses] The authors investigated the susceptibility of camelids to SARS-CoV-2 using novel well-differentiated camelid nasal organoids. They showed that camelid nasal organoids are highly susceptible to Middle East respiratory syndrome coronavirus infection, but not to infection with different SARS-CoV-2 variants.

[Development] Researchers identified conditions enabling mouse thymic epithelial progenitor cell proliferation and development into organoids with diverse cell populations and transcriptional profiles resembling in vivo thymic epithelial cells (TECs) more closely than traditional TEC cultures.

[PLOS One] The authors elucidated the potential of melatonin and misoprostol to reduce 5-fluorouracil-induced small intestinal mucositis. Morphological and cellular changes in the jejunum, along with colonic faecal water content were quantified in rats as markers for chemotherapy-induced mucositis.

[Matrix Biology] Intestinal organoids derived from mouse colon were grown in normal glucose media (5 mM) or high glucose media (25 mM) to study the impact of hyperglycemic stress on the intestinal barrier.

[Current Stem Cell Research & Therapy] Human salivary gland stem cells were isolated from the salivary gland tissues and cultured in both Matrigel and collagen. Investigators compared the gene and protein expression patterns of salivary gland–specific markers and measured amylase activity in the two types of human salivary gland organoids.