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Development and Characterization of Islet-Derived Mesenchymal Stem Cells from Clinical Grade Neonatal Porcine Cryopreserved Islets

[Xenotransplantation] MSCs were established from fresh and cryopreserved non-clinical grade neonatal porcine islets and bone marrow, as well as from cryopreserved clinical grade neonatal porcine islets.

M2 Macrophage-Secreted Exosomes Promote Metastasis and Increase Vascular Permeability in Hepatocellular Carcinoma

[Cell Communication And Signaling] Exosomes derived from M2 macrophages were characterized. Then, hepatocellular carcinoma cells or human umbilical vein endothelial cells were co-cultured with M2 macrophages or treated with M2 macrophage-secreted exosomes.

Extracellular Vesicles Derived from Human Umbilical Cord MSC Improve Vascular Endothelial Function in In Vitro and In Vivo Models of Preeclampsia through Activating Arginine...

[Molecular Pharmaceutics] Researchers explored the possible mechanism of human umbilical mesenchymal stem-cell-derived extracellular vesicles (HUMSCs-derived EVs) in the treatment of endothelial cell injury. The changes of metabolites in endothelial cells after HUMSCs-derived EVs treatment were analyzed by metabolomics analysis and further validated by cell experiments.

A Systematic Review and Meta-Analysis of the Global Prevalence and Determinants of COVID-19 Vaccine Acceptance and Uptake in People Living with HIV

[Nature Human Behaviour] Scientists reported the pooled prevalence of COVID-19 vaccine acceptance/uptake and determinants among this vulnerable population of people living with HIV based on a systematic review and meta-analysis of studies published by 25 August 2023.

CD70-Induced Differentiation of Proinflammatory Th1/17/22/GM Lymphocytes Associated with Disease Progression and Immune Reconstitution During HIV Infection

[Virologica Sinica] Researchers highlighted the role of CD70 in Th1/17/22/GM differentiation during HIV infection and provided evidence for CD70 as a potential biomarker for predicting immune recovery.

Human ApoE2 Protects Mice Against Plasmodium berghei ANKA Experimental Cerebral Malaria

[mBio] Human apolipoprotein E (hApoE) mice infected with Plasmodium berghei ANKA showed increased splenomegaly and IFN-γ levels in serum but reduced cerebral cell apoptosis that correlated with the survival advantage against experimental cerebral malaria.

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