Publication

[Journal Of Cellular And Molecular Medicine] Scientists showed that the ex vivo expansion and activation of cytokine-induced killer cells isolated from primary peripheral blood mononuclear cells induced immune-mediated apoptosis in both human prostate cancer cells.

[Cancer Medicine] The authors reconstructed the lncRNA-centered regulatory network of mCRPC and identified the lncRNAs which act as master regulators.

[Experimental Biology and Medicine] Using PC-3 human prostate cancer cells, investigators found that resistin upregulated the expression of suppressor of cytokine signaling 3 (SOCS3) and SOCS5 mRNA, but not SOCS7 mRNA, in a dose- and time-dependent manner.

[The Prostate] Researchers assessed the impact of these androgen receptor (AR) alterations on survival outcomes in a real-world patient population of mCRPC experiencing disease progression on an AR pathway inhibitor.

[Hepatology] After generating transgenic mice that overexpressed the PiZ variant and simultaneously harbored the patatin-like phospholipase domain-containing protein 3 (PNPLA3)I148M knockin, scientists observed that PiZ and PiZ/PNPLA3I148M animals showed increased liver enzymes compared to controls during aging.

[Cell Death & Disease] Researchers examined the role of cyclin E1 and Cdk2 genes in hepatic stellate cells for liver fibrogenesis and hepatocarcinogenesis.