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Mesenchymal Cell News
NUCKS1, a LINC00629-Upregulated Gene, Facilitated Osteosarcoma Progression and Metastasis by Elevating Asparagine Synthesis
[Cell Death & Disease] Researchers reported that NUCKS1 was significantly increased in osteosarcoma. Depletion of NUCKS1 decreased osteosarcoma cell proliferation and metastasis in vivo and in vitro.
Mesenchymal Cell News
Skin Mesenchymal Niches Maintain and Protect AML-Initiating Stem Cells
[Journal Of Experimental Medicine] Scientists reported massive acute myeloid leukemia (AML) cell infiltration in the skin in a transplantation-induced MLL-AF9 AML mouse model. These AML cells could regenerate AML after transplantation. Prospective niche characterization revealed that skin harbored mesenchymal progenitor cells with a similar phenotype as BM mesenchymal stem cells.
Extracellular Matrix News
Effects of Atrazine Exposure on Human Bone Marrow-Derived Mesenchymal Stromal Cells Assessed by Combinatorial Assay Matrix
[Frontiers In Immunology] The authors employed the combinatorial assay matrix approach, including a panel of well standardized assays, such as flow cytometry, multiplex secretome analysis, and metabolic assays, to define the phenotype and functionality of human-donor-derived primary MSCs exposed to the representative xenobiotic Atrazine.
Cancer Stem Cell News
Coexisting Cancer Stem Cells with Heterogeneous Gene Amplifications, Transcriptional Profiles, and Malignancy Are Isolated from Single Glioblastomas
[Cell Reports] Investigators describe the systematic derivation, propagation, and characterization of multiple distinct glioblastoma stem cells from single, treatment-naive glioblastoma.
Extracellular Matrix News
Ablation of the Carboxy-Terminal End of MAMDC2 Causes a Distinct Muscular Dystrophy
[Brain] The authors described 17 individuals with an autosomal dominant muscular dystrophy belonging to two unrelated families in which different heterozygous truncating variants in the last exon of MAMDC2 co-segregate correctly with the disease.
Newsletters
Schwann Cells Regulate Tumor Cells and Cancer-Associated Fibroblasts in the Pancreatic Ductal Adenocarcinoma Microenvironment
[Nature Communications] In vitro and in vivo assays demonstrated that Schwann cells enhanced the proliferation and migration of PDAC cells via Midkine signaling, and promoted the switch of cancer-associated fibroblasts (CAFs) to basal-like and inflammatory CAFs via interleukin-1α.