Scientists discuss the progress made in induced pluripotent stem cells (iPSC)-derived T cells and provides a roadmap for the development of CAR iPSC-derived T cells and off-the-shelf T-iPSCs.
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Sadeqi Nezhad, M., Abdollahpour-Alitappeh, M., Rezaei, B., Yazdanifar, M., & Seifalian, A. M. (2021). Induced Pluripotent Stem Cells (iPSCs) Provide a Potentially Unlimited T Cell Source for CAR-T Cell Development and Off-the-Shelf Products. Pharmaceutical Research. https://doi.org/10.1007/s11095-021-03067-z Cite
The authors summarize the androgen receptor heterogeneity across the prostate cancer (PCa) continuum and discuss its impact on PCa response to treatments.
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Scientists discuss the promise of immunotherapy in prostate cancer treatment with an emphasis on emerging therapeutic targets. Most prostate tumors have low tumor mutational burden and lack immunogenicity, representing significant hurdles to induction of anti-tumor immunity.
[Current Oncology Reports]
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The potential of 3D bioprinting for skin applications was presented, highlighting the development of patch-like skin constructs for wound and burn treatment, and skin equivalents for in vitro research and drug development.
[International Journal of Pharmaceutics]
Scientists summarize the key findings on TCF1 across the fields of T cell immunity and reflect on the possibility of exploring TCF1 and its downstream transcriptional programmes as therapeutic targets for improving antiviral and antitumour immunity.
[Nature Reviews Immunology]
Investigators discuss the multifaceted heart problem in the course of Duchenne muscular dystrophy, balancing the insights into basic science, translational efforts and clinical manifestation of dystrophic heart disease.
[Cellular and Molecular Life Sciences]
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Scientists discuss the contributions of inflammation and infection to venous thromboembolism.
Scientists review the current knowledge and crucial information about how SARS-CoV-2 attaches on the surface of host cells through a variety of receptors, such as ACE2, neuropilin-1, AXL, and antibody–FcγR complexes.
[Signal Transduction and Targeted Therapy]
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The authors review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies.
[Nature Reviews Immunology]
Scientists summarize the potential mechanisms and therapeutic effects of MSC-derived exosomes in cardiac regeneration and repair and provide evidence to support their clinical application.
[Stem Cell Reports]
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The authors survey recent observations that are shedding more light on the nature of the interaction between circadian rhythms and the vascular system with implications for blood vessel disease.
[Current Opinion in Pharmacology]
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