The authors define the role of administrating fecal microbiota transplantation in the setting of allogeneic hematopoietic stem cell transplantation.
Scientists discuss the roles of immunomodulatory receptors in the control of immunity from a perspective focused on therapeutic potential in not only cancer but also autoimmune diseases.
[Cellular & Molecular Immunology]
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The liver is an immunologic organ with large populations of innate and innate-like immune cells and is exposed to bacterial, viral, and fungal antigens through the gut–liver axis. Scientists summarize and highlight the role of these cells in liver cancer and propose strategies to therapeutically target them.
[Cellular & Molecular Immunology]
Scientists outline methodological approaches for measuring immunogenic cell death markers in vitro and ex vivo for the discovery of next-generation antineoplastic agents, the development of personalized anticancer regimens, and the identification of optimal therapeutic combinations for the clinical management of cancer.
[Cell Death & Disease]
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Scientists review the latest molecular and cellular findings on the mucosal response to SARS-CoV-2 in the nasal cavity and in Nasopharynx-Associated Lymphoid Tissue, and to analyze its impact in the subsequent course of COVID-19.
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The authors provide an overview of the therapeutic option for brain metastases from breast cancer that is currently available and outlines potential new approaches for tackling these deadly secondary tumors.
[British Journal of Cancer]
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Olah, M., Menon, V., Habib, N., Taga, M. F., Ma, Y., Yung, C. J., Cimpean, M., Khairallah, A., Coronas-Samano, G., Sankowski, R., Grün, D., Kroshilina, A. A., Dionne, D., Sarkis, R. A., Cosgrove, G. R., Helgager, J., Golden, J. A., Pennell, P. B., Prinz, M., … De Jager, P. L. (2020). Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease. Nature Communications, 11(1), 6129. https://doi.org/10.1038/s41467-020-19737-2 Cite
Scientists discuss recent findings of miR‐128 in relation to bone metabolism and muscle regeneration to determine its potential therapeutic effects in musculoskeletal diseases, and to propose directions for future research in this significant field.
[Journal of Cellular Physiology]
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Shang, Q., Shen, G., Chen, G., Zhang, Z., Yu, X., Zhao, W., Zhang, P., Chen, H., Tang, K., Yu, F., Tang, J., Liang, D., Jiang, X., & Ren, H. (n.d.). The emerging role of miR-128 in musculoskeletal diseases. Journal of Cellular Physiology, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcp.30179 Cite
The authors discuss the recent advances in the field of epigenetics of non-melanoma skin cancer. Particularly, the role of DNA methylation, histone hyperacetylation and non-coding RNA such as long-chain noncoding RNAs, circular RNAs and miRNA in the disease progression are summarized.
[Seminars in Cancer Biology]
Investigators provide striking evidence that the degeneration of astrocytes and oligodendrocytes, in addition to inhibitory and modulatory interneurons, disrupt the functionally coherent environment of motoneurons. They discuss the extent to which the degeneration of glial cells and interneurons also contributes to the decline of the motor system.
The authors expand on the clinical development of PARP inhibitors (PARPis) in metastatic castration-resistant prostate cancer, discuss potential biomarkers that may predict successful tumor control, and summarize present and future clinical research on PARPis in the metastatic disease landscape.
Investigators summarize pre-term white matter injury pathogenesis and pathophysiology, and the specific properties of different cell types in umbilical cord blood.
[Journal of Neuroscience Research]
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