Tag Archives: type-review

Latest Culture Techniques: Cracking the Secrets of Bone Marrow to Mass-Produce Erythrocytes and Platelets Ex Vivo

Scientists discuss the latest culture techniques and technological approaches to obtain functional platelets and erythrocytes ex vivo.
[Haematologica]
Buduo, C. A. D., Aguilar, A., Soprano, P. M., Bocconi, A., Miguel, C. P., Mantica, G., & Balduini, A. (2020). Latest culture techniques: cracking the secrets of bone marrow to mass-produce erythrocytes and platelets <i>ex vivo. Haematologica. https://doi.org/10.3324/haematol.2020.262485 Cite
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A Closer Look at Estrogen Receptor Mutations in Breast Cancer and Their Implications for Estrogen and Antiestrogen Responses

The authors summarize the latest advances regarding the particular involvement of point mutations of estrogen receptor alpha (ERα) in endocrine resistance. They also discuss the involvement of synonymous ERα mutations with respect to co-translational folding of the receptor and ribosome biogenesis in breast carcinogenesis.
[International Journal of Molecular Sciences]
Clusan, L., Le Goff, P., Flouriot, G., & Pakdel, F. (2021). A Closer Look at Estrogen Receptor Mutations in Breast Cancer and Their Implications for Estrogen and Antiestrogen Responses. International Journal of Molecular Sciences, 22(2), 756. https://doi.org/10.3390/ijms22020756 Cite
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A High-Dimensional Window into the Micro-Environment of Triple Negative Breast Cancer

Investigators discuss the cellular phenotypes and spatial patterns of the lymphoid-, myeloid-, and stromal cells in the TNBC microenvironment and the potential value of mapping these features onto tumor cell genotypes.
[Cancers]
Nederlof, I., Horlings, H. M., Curtis, C., & Kok, M. (2021). A High-Dimensional Window into the Micro-Environment of Triple Negative Breast Cancer. Cancers, 13(2), 316. https://doi.org/10.3390/cancers13020316 Cite
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Interplay between Cofactors and Transcription Factors in Hematopoiesis and Hematological Malignancies

Investigators summarize the current knowledge regarding the models and functions of cofactor–transcription factor interplay in physiological hematopoiesis and highlight their implications in the etiology of hematological malignancies.
[Signal Transduction and Targeted Therapy]
Wang, Z., Wang, P., Li, Y., Peng, H., Zhu, Y., Mohandas, N., & Liu, J. (2021). Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies. Signal Transduction and Targeted Therapy, 6(1), 1–16. https://doi.org/10.1038/s41392-020-00422-1 Cite
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Pathophysiology of Sepsis-Induced Cardiomyopathy

Researchers explore the definition, epidemiology, diagnosis and pathophysiology of septic cardiomyopathy, with an emphasis on how best to interpret this condition in the clinical context.
[Nature Reviews Cardiology]
Hollenberg, S. M., & Singer, M. (2021). Pathophysiology of sepsis-induced cardiomyopathy. Nature Reviews Cardiology, 1–11. https://doi.org/10.1038/s41569-020-00492-2 Cite
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Considerations for the Bioengineering of Advanced Cardiac In Vitro Models of Myocardial Infarction

Scientists highlight the major features typical of a heart attack while comparing current in vitro, ex vivo, and in vivo models. This information has the potential to further guide in developing novel advanced in vitro cardiac models of ischemia/reperfusion injury.
[Small]
Sharma, P., Wang, X., Ming, C. L. C., Vettori, L., Figtree, G., Boyle, A., & Gentile, C. (n.d.). Considerations for the Bioengineering of Advanced Cardiac In Vitro Models of Myocardial Infarction. Small, n/a(n/a), 2003765. https://doi.org/https://doi.org/10.1002/smll.202003765 Cite
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The Improbable Targeted Therapy: KRAS as an Emerging Target in Non-Small Cell Lung Cancer (NSCLC)

The authors review promising therapeutics tested for KRAS mutant non-small cell lung cancer.
[Cell Reports Medicine]
Salgia, R., Pharaon, R., Mambetsariev, I., Nam, A., & Sattler, M. (2021). The improbable targeted therapy: KRAS as an emerging target in non-small cell lung cancer (NSCLC). Cell Reports Medicine, 2(1). https://doi.org/10.1016/j.xcrm.2020.100186 Cite
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Liquid Biopsy Enters the Clinic – Implementation Issues and Future Challenges

The authors discuss key issues and gaps in technology, clinical trial methodologies and logistics for the eventual integration of liquid biopsy into the clinical workflow.
[Nature Reviews Clinical Oncology]
Ignatiadis, M., Sledge, G. W., & Jeffrey, S. S. (2021). Liquid biopsy enters the clinic — implementation issues and future challenges. Nature Reviews Clinical Oncology, 1–16. https://doi.org/10.1038/s41571-020-00457-x Cite
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MicroRNA Regulation of Cancer Stem Cells in the Pathogenesis of Breast Cancer

Investigators summarize the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the breast cancer stem cell maintenance.
[Cancer Cell International]
Niu, T., Zhang, W., & Xiao, W. (2021). MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer. Cancer Cell International, 21(1), 31. https://doi.org/10.1186/s12935-020-01716-8 Cite
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Amniotic Fluid Stem Cells as a Novel Strategy for the Treatment of Fetal and Neonatal Neurological Diseases

Investigators outline the results of preclinical research on fetal stem cell therapy, mainly involving human amniotic fluid stem cells, in the context of perinatal neurological diseases.
[Placenta]
Abe, Y., Ochiai, D., Sato, Y., Otani, T., Fukutake, M., Ikenoue, S., Kasuga, Y., & Tanaka, M. (2021). Amniotic fluid stem cells as a novel strategy for the treatment of fetal and neonatal neurological diseases. Placenta, 104, 247–252. https://doi.org/10.1016/j.placenta.2021.01.009 Cite
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The Renaissance of Chemically Generated Bispecific Antibodies

Investigators review chemical methods for the generation of bsAbs, showing that the newest examples of these techniques are worthy competitors to the industry-standard expression-based strategies.
[Nature Reviews Chemistry]
Szijj, P., & Chudasama, V. (2021). The renaissance of chemically generated bispecific antibodies. Nature Reviews Chemistry, 1–15. https://doi.org/10.1038/s41570-020-00241-6 Cite
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