Induced Pluripotent Stem Cells (iPSCs) Provide a Potentially Unlimited T Cell Source for CAR-T Cell Development and Off-the-Shelf Products

Scientists discuss the progress made in induced pluripotent stem cells (iPSC)-derived T cells and provides a roadmap for the development of CAR iPSC-derived T cells and off-the-shelf T-iPSCs.
[Pharmaceutical Research]
Sadeqi Nezhad, M., Abdollahpour-Alitappeh, M., Rezaei, B., Yazdanifar, M., & Seifalian, A. M. (2021). Induced Pluripotent Stem Cells (iPSCs) Provide a Potentially Unlimited T Cell Source for CAR-T Cell Development and Off-the-Shelf Products. Pharmaceutical Research. https://doi.org/10.1007/s11095-021-03067-z Cite
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Androgen Receptor (AR) Heterogeneity in Prostate Cancer and Therapy Resistance

The authors summarize the androgen receptor heterogeneity across the prostate cancer (PCa) continuum and discuss its impact on PCa response to treatments.
[Cancer Letters]
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Prostate Cancer Immunotherapy-Finally in from the Cold?

Scientists discuss the promise of immunotherapy in prostate cancer treatment with an emphasis on emerging therapeutic targets. Most prostate tumors have low tumor mutational burden and lack immunogenicity, representing significant hurdles to induction of anti-tumor immunity.
[Current Oncology Reports]
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Diving into 3D (Bio)Printing: A Revolutionary Tool to Customize the Production of Drug and Cell-Based Systems for Skin Delivery

The potential of 3D bioprinting for skin applications was presented, highlighting the development of patch-like skin constructs for wound and burn treatment, and skin equivalents for in vitro research and drug development.
[International Journal of Pharmaceutics]
Diving into 3D (bio)printing: A revolutionary tool to customize the production of drug and cell-based systems for skin delivery. (2021). International Journal of Pharmaceutics, 605, 120794. https://doi.org/10.1016/j.ijpharm.2021.120794 Cite
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TCF1 in T Cell Immunity: A Broadened Frontier

Scientists summarize the key findings on TCF1 across the fields of T cell immunity and reflect on the possibility of exploring TCF1 and its downstream transcriptional programmes as therapeutic targets for improving antiviral and antitumour immunity.
[Nature Reviews Immunology]
Zhao, X., Shan, Q., & Xue, H.-H. (2021). TCF1 in T cell immunity: a broadened frontier. Nature Reviews Immunology, 1–11. https://doi.org/10.1038/s41577-021-00563-6 Cite
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The Multifaceted View of Heart Problem in Duchenne Muscular Dystrophy

Investigators discuss the multifaceted heart problem in the course of Duchenne muscular dystrophy, balancing the insights into basic science, translational efforts and clinical manifestation of dystrophic heart disease.
[Cellular and Molecular Life Sciences]
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Inflammation, Infection and Venous Thromboembolism

Scientists discuss the contributions of inflammation and infection to venous thromboembolism.
[Circulation Research]
Colling, M. E., Tourdot, B. E., & Kanthi, Y. (2021). Inflammation, Infection and Venous Thromboembolism. Circulation Research, 128(12), 2017–2036. https://doi.org/10.1161/CIRCRESAHA.121.318225 Cite
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Molecular Mechanism of Interaction between SARS-CoV-2 and Host Cells and Interventional Therapy

Scientists review the current knowledge and crucial information about how SARS-CoV-2 attaches on the surface of host cells through a variety of receptors, such as ACE2, neuropilin-1, AXL, and antibody–FcγR complexes.
[Signal Transduction and Targeted Therapy]
Zhang, Q., Xiang, R., Huo, S., Zhou, Y., Jiang, S., Wang, Q., & Yu, F. (2021). Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy. Signal Transduction and Targeted Therapy, 6(1), 1–19. https://doi.org/10.1038/s41392-021-00653-w Cite
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Natural Killer Cells in Antiviral Immunity

The authors review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies.
[Nature Reviews Immunology]
Björkström, N. K., Strunz, B., & Ljunggren, H.-G. (2021). Natural killer cells in antiviral immunity. Nature Reviews Immunology, 1–12. https://doi.org/10.1038/s41577-021-00558-3 Cite
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Mesenchymal Stromal Cell-Derived Exosomes in Cardiac Regeneration and Repair

Scientists summarize the potential mechanisms and therapeutic effects of MSC-derived exosomes in cardiac regeneration and repair and provide evidence to support their clinical application.
[Stem Cell Reports]
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Review: Circadian Clocks and Rhythms in the Vascular Tree

The authors survey recent observations that are shedding more light on the nature of the interaction between circadian rhythms and the vascular system with implications for blood vessel disease.
[Current Opinion in Pharmacology]
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