T Cell Regeneration after Immunological Injury

The authors focus on the causes and consequences of impaired adaptive immunity and discuss therapeutic strategies that can recover immune function, with a particular emphasis on approaches that can promote a diverse repertoire of T cells through de novo T cell formation.
[Nature Reviews Immunology]
Velardi, E., Tsai, J. J., & van den Brink, M. R. M. (2020). T cell regeneration after immunological injury. Nature Reviews Immunology, 1–15. https://doi.org/10.1038/s41577-020-00457-z Cite
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Self-Amplifying RNA Vaccines for Infectious Diseases

Scientists explore how self-amplifying RNAs are emerging as important vaccine candidates for infectious diseases, the advantages of synthetic manufacturing approaches, and their potential for preventing and treating chronic infections.
[Gene Therapy]
Bloom, K., van den Berg, F., & Arbuthnot, P. (2020). Self-amplifying RNA vaccines for infectious diseases. Gene Therapy, 1–13. https://doi.org/10.1038/s41434-020-00204-y Cite
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Resistance Mechanisms to Antimicrobial Peptides in Gram-Positive Bacteria

The authors discuss the mechanisms exploited by Gram-positive bacteria to circumvent killing by antimicrobial peptides. Specifically, the most clinically relevant genera, Streptococcus spp., Staphylococcus spp., Enterococcus spp. and Gram-positive bacilli, have been explored.
[Frontiers in Microbiology]
Assoni, L., Milani, B., Carvalho, M. R., Nepomuceno, L. N., Waz, N. T., Guerra, M. E. S., Converso, T. R., & Darrieux, M. (2020). Resistance Mechanisms to Antimicrobial Peptides in Gram-Positive Bacteria. Frontiers in Microbiology, 11. https://doi.org/10.3389/fmicb.2020.593215 Cite
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Toward a Consensus View of Mammalian Adipocyte Stem and Progenitor Cell Heterogeneity

The authors present current knowledge on adipose stem and progenitor cells (ASPCs), their population structure, hierarchy, fat depot-specific nature, function, and regulatory mechanisms, and discuss not only the similarities, but also the differences between mouse and human ASPC biology.
[Trends in Cell Biology]
Ferrero, R., Rainer, P., & Deplancke, B. (2020). Toward a Consensus View of Mammalian Adipocyte Stem and Progenitor Cell Heterogeneity. Trends in Cell Biology, 0(0). https://doi.org/10.1016/j.tcb.2020.09.007 Cite
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Advances in Resolving the Heterogeneity and Dynamics of Keratinocyte Differentiation

Investigators highlight major recent discoveries that illuminate the dynamics and cellular mechanisms that govern keratinocyte differentiation in the live mammalian skin and discuss the broader implications of these findings for our understanding of epithelial and stem cell biology in general.
[Current Opinion in Cell Biology]
Rice, G., & Rompolas, P. (2020). Advances in resolving the heterogeneity and dynamics of keratinocyte differentiation. Current Opinion in Cell Biology, 67, 92–98. https://doi.org/10.1016/j.ceb.2020.09.004 Cite
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Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease

The authors discuss how the recently defined functions of these Alzheimer’s disease (AD) risk genes can be targeted therapeutically to modulate microglial cell state and slow the progression of AD.
[Neuron]
Lewcock, J. W., Schlepckow, K., Paolo, G. D., Tahirovic, S., Monroe, K. M., & Haass, C. (2020). Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease. Neuron, 0(0). https://doi.org/10.1016/j.neuron.2020.09.029 Cite
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Modeling Human Neuronal Migration Deficits in 3D

Scientists provide a short introduction on human and mouse neuronal migration processes, and highlight human brain organoid models of neuronal migration diseases.
[Current Opinion in Neurobiology]
Reiner, O., Parichha, A., & Sapir, T. (2021). Modeling human neuronal migration deficits in 3D. Current Opinion in Neurobiology, 66, 30–36. https://doi.org/10.1016/j.conb.2020.09.005 Cite
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Extracellular Vesicles from Organoids and 3D Culture Systems

The author provides a comprehensive picture of the progress using 3D in vitro culture models for extracellular vesicle analysis.
[Biotechnology and Bioengineering]
Abdollahi, S. (n.d.). Extracellular vesicles from organoids and 3D culture systems. Biotechnology and Bioengineering, n/a(n/a). https://doi.org/10.1002/bit.27606 Cite
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Organoids to Model Liver Disease

Organoid models offer new perspectives in personalized medicine and drug discovery. The authors discuss the current liver organoid models for the study of liver disease.
[JHEP Reports]
Nuciforo, S., & Heim, M. H. (2020). Organoids to model liver disease. JHEP Reports, 100198. https://doi.org/10.1016/j.jhepr.2020.100198 Cite
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Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration

The authors focus on the regionally distinct lung epithelial cell types that contribute to repair after injury, and they address current controversies regarding whether elite stem cells or frequent facultative progenitors are the predominant participants.
[Annual Review of Physiology]
Alysandratos, K.-D., Herriges, M. J., & Kotton, D. N. (2021). Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration. Annual Review of Physiology, 83(1), null. https://doi.org/10.1146/annurev-physiol-041520-092904 Cite
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Epigenetic Regulators as the Gatekeepers of Hematopoiesis

Researchers bring together what is currently known about chromatin status and the development of cells in the hematopoietic system under normal and abnormal conditions.
[Trends in Genetics]
Rodrigues, C. P., Shvedunova, M., & Akhtar, A. (2020). Epigenetic Regulators as the Gatekeepers of Hematopoiesis. Trends in Genetics, 0(0). https://doi.org/10.1016/j.tig.2020.09.015 Cite
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