Scientists discuss the latest culture techniques and technological approaches to obtain functional platelets and erythrocytes ex vivo.
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The authors summarize the latest advances regarding the particular involvement of point mutations of estrogen receptor alpha (ERα) in endocrine resistance. They also discuss the involvement of synonymous ERα mutations with respect to co-translational folding of the receptor and ribosome biogenesis in breast carcinogenesis.
[International Journal of Molecular Sciences]
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Investigators discuss the cellular phenotypes and spatial patterns of the lymphoid-, myeloid-, and stromal cells in the TNBC microenvironment and the potential value of mapping these features onto tumor cell genotypes.
Investigators summarize the current knowledge regarding the models and functions of cofactor–transcription factor interplay in physiological hematopoiesis and highlight their implications in the etiology of hematological malignancies.
[Signal Transduction and Targeted Therapy]
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Researchers explore the definition, epidemiology, diagnosis and pathophysiology of septic cardiomyopathy, with an emphasis on how best to interpret this condition in the clinical context.
[Nature Reviews Cardiology]
Scientists highlight the major features typical of a heart attack while comparing current in vitro, ex vivo, and in vivo models. This information has the potential to further guide in developing novel advanced in vitro cardiac models of ischemia/reperfusion injury.
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Sharma, P., Wang, X., Ming, C. L. C., Vettori, L., Figtree, G., Boyle, A., & Gentile, C. (n.d.). Considerations for the Bioengineering of Advanced Cardiac In Vitro Models of Myocardial Infarction. Small, n/a(n/a), 2003765. https://doi.org/https://doi.org/10.1002/smll.202003765 Cite
The authors review promising therapeutics tested for KRAS mutant non-small cell lung cancer.
[Cell Reports Medicine]
The authors discuss key issues and gaps in technology, clinical trial methodologies and logistics for the eventual integration of liquid biopsy into the clinical workflow.
[Nature Reviews Clinical Oncology]
Investigators summarize the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the breast cancer stem cell maintenance.
[Cancer Cell International]
Investigators outline the results of preclinical research on fetal stem cell therapy, mainly involving human amniotic fluid stem cells, in the context of perinatal neurological diseases.
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Investigators review chemical methods for the generation of bsAbs, showing that the newest examples of these techniques are worthy competitors to the industry-standard expression-based strategies.
[Nature Reviews Chemistry]