Tag Archives: type-review

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Pre-Clinical Modeling of Cutaneous Melanoma

The authors discuss the current available repertoire of melanoma models including two- and three-dimensional tissue cultures, organoids, genetically engineered mice and patient-derived xenograft.

[Nature Communications]

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Mitochondria in Skin Health, Aging, and Disease

Scientists discuss the essential role of mitochondria in regulating normal and abnormal skin physiology and the possibility of targeting this organelle in various skin disorders.

[Cell Death & Disease]

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Full Article Graphical Abstract

MicroRNAs in Hematopoietic Stem Cell Aging

The authors discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.

[Mechanisms of Ageing and Development]

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Advances in the Development of Gene Therapy, Noncoding RNA, and Exosome‐Based Treatments for Tendinopathy

The authors summarize the current understanding and treatments for tendinopathy. They also highlight recent advances in gene therapy, the potential of noncoding RNAs, such as microRNAs, and exosomes, which are nanometer‐sized extracellular vesicles secreted from cells, for the treatment of tendinopathy.

[Annals of the New York Academy of Sciences]

Abstract

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The Role of B Cells in Heart Failure and Implications for Future Immunomodulatory Treatment Strategies

B cells produce antibodies that interfere with cardiomyocyte function, which culminates as the result of recruitment and activation of a variety of innate and structural cell populations, including neutrophils, macrophages, fibroblasts, and T cells.

[ESC Heart Failure]

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The Tumor Microenvironment in Cholangiocarcinoma Progression

Investigators summarize current understandings of the tumor microenvironment and intercellular communications in cholangiocarcinoma and their role in tumor progression.

[Hepatology]

Abstract

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Innervation: The Missing Link for Biofabricated Tissues and Organs

The authors assert that innervation should be included as a necessary component for tissue and organ biofabrication, and that strategies to orchestrate host axonal integration are advantageous to ensure proper function, tolerance, assimilation, and bio-regulation with the recipient post-implant.

[NPJ Regenerative Medicine]

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Materials Design for Bone-Tissue Engineering

The authors provide an overview of materials-design considerations for bone-tissue-engineering applications in both disease modeling and treatment of injuries and disease in humans.

[Nature Reviews Materials]

Abstract

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Publication

Targeting Focal Adhesion Kinase in Cancer Cells and the Tumor Microenvironment

Scientists discuss the role of nuclear focal adhesion kinase (FAK) as a driver for tumor cell survival as well as potential therapeutic strategies to target FAK in both tumors and the tumor microenvironment

[Experimental and Molecular Medicine]

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Publication

Prevention of Tumor Risk Associated with the Reprogramming of Human Pluripotent Stem Cells

The authors focus on the risk of tumor formation by human PSCs, and on the possible treatment options if it occurs. Potential new techniques that target epigenetic processes and chromatin regulation provide opportunities for human cancer modeling and regenerative medicine.

[Journal of Experimental & Clinical Cancer Research]