Review

[Reviews In Medical Virology] The authors explore how HIV has evolved to manipulate some of the physiological roles of these cells, thereby gaining access to strategic cellular niches that are critical for the spread and pathogenesis of HIV infection.

[Biomolecules & Biomedicine] Stem cell therapy still faces multiple challenges, such as the durability and survival of MSCs upon implantation, uncertain pathways to discogenic differentiation, and the adverse impact of a harsh microenvironment on cell survival.

[Cancer Discovery] Investigators discuss the role of SHP2 in cancer and the tumor microenvironment, and the clinical strategies in which SHP2 inhibitors are leveraged as combination agents to improve therapeutic response.

[Cell Death & Disease] The authors elucidate the relationship between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment , with the ultimate goal of identifying novel therapeutic targets and charting new avenues for immunotherapy.

[Nature Reviews Materials] Scientists summarize studies using biomaterials as extracellular matrix with tenable properties to manipulate macrophage–endothelial cell fate to regulate innate and adaptive immunity, angiogenesis and regeneration.

[Blood] The authors summarize previously recognized and more recent studies that have elucidated how anucleate, small platelets manage to maintain vascular integrity when faced with challenges of infection, sterile inflammation and even malignancy. They dissect how platelets are recruited to the vascular wall, how they identify sites of injury, and how they prevent hemorrhage as single cells.