Review

[Military Medical Research] The authors provide a comprehensive overview of the current status of mesenchymal stem cell-derived extracellular vesicles-based therapies in skin wound healing, application potential, and associated drawbacks.

[Nature Reviews Cardiology] The authors provide an overview of the diverse array of vertebrates that have been studied for their cardiac regenerative potential and discuss differential heart regeneration outcomes in closely related species.

[Trends in Pharmacological Sciences] Scientists discuss emerging pathways that regulate muscle atrophy, including oncostatin M, and ectodysplasin A2 receptor signaling, outcomes of recent clinical trials, and potential drug targets for future therapies.

[Biomedicine & Pharmacotherapy] In the early stages of systemic sclerosis development, endothelial cell injury and apoptosis can lead to vascular and perivascular inflammation, oxidative stress, and tissue hypoxia, which can cause clinical manifestations in various organs from the skin to the parenchymal organs.

[Nature Cardiovascular Research] Scientists analyze how extracellular matrix (ECM) mechanics regulate vascular homeostasis and dysfunction, highlighting approaches to examine ECM mechanics at tissue and cellular levels, focusing on how mechanical interactions between cells and the ECM regulate vascular phenotype, especially under certain pathological conditions.

[Signal Transduction And Targeted Therapy] The authors review historical perspectives on the applications and clinical considerations of immunotherapy. They first outline the recent advances that have been made in the understanding of the various categories of immunotherapies in the treatment of hematologic malignancies.