Publication

[Communications Biology] Researchers showed that eliminating abnormal bone marrow-derived cells using bone marrow transplantation resulted in controlling serum glucose in diabetic mice, in which normoglycemia was sustained even after cessation of insulin therapy.

[Molecular Cancer Therapeutics] Using a combination of patient and syngeneic murine models, scientists investigated the effects of the Bromo- and Extra-Terminal domain drug BMS-986158 on cellular proliferation, organoid growth, cell cycle progression, and mitochondrial metabolic disruption.

[Scientific Reports] Scientists found that MTAP-ANRIL gene fusion downregulated the expression of wild-type MTAP and promoted epithelial-mesenchymal transition-like process through the activation of JNK and p38 MAPKs in vitro and in vivo.

[Scientific Reports] In vitro, recombinant microfibril-associated protein 5 significantly enhanced dermal fibroblast migration, collagen contractility, and expression of pro-fibrotic genes.

[Cell Death & Disease] SLC35E1 deficiency inhibited keratinocyte proliferation in both mice and cultured cells. On a molecular level, SLC35E1 was found to regulate zinc ion concentrations and subcellular localization, while zinc ion chelation reversed the imiquimod-induced psoriatic phenotype in Slc35e1−/− mice.

[Nature Aging] Mechanistically, aberrant interleukin (IL)-17 signalled through NF-κB in epidermal cells to impair homeostatic functions while promoting an inflammatory state.