Publication

[Nature Communications] With omics and functional assays deploying patient-derived in vitro and in vivo models, scientists showed that macroH2A2 shaped chromatin accessibility at enhancer elements to antagonize transcriptional programs of self-renewal.

[Cell Reports] Using small-molecule modulators and genetic perturbations, researchers identified a synergistic interaction between FOXG1 and Wnt/β-catenin signaling.

[Clinical Epigenetics] The authors investigated the biological functions and mechanisms involved in the SET and MYND domain-containing protein 3 (SMYD3)-mediated tumorigenesis of oral squamous cell carcinoma utilizing bioinformatic approaches and validation assays.

[Ecotoxicology and Environmental Safety] Scientists reported for the first time that JWA was significantly downregulated in smoking-related lung cancer and associated with overall survival. Nicotine exposure reduced JWA expression in a dose-dependent manner.

[Oncogenesis] Researchers showed that the AKT-mediated phosphorylation of the transcription elongation factor IWS1, promoted the maintenance of CSCs in both cell and xenograft models of liposarcoma.

[Journal of Cellular and Molecular Medicine] The authors investigated the altered lncRNAs upon endoplasmic reticulum (ER) stress in glioma and found that small nucleolar RNA host gene 1 (SNHG1) was markedly increased in response to ER stress.