Publication

[Science Immunology] Deep immune profiling using single-cell RNA and repertoire sequencing of peripheral blood mononuclear cells during acute disease revealed expansion of activated CXCR3+ cytotoxic T cells and natural killer cells, both phenotypically resembling cytokine-driven killer cells.

[Immunity] Based on identification of theT cell receptor repertoire and functionality landscape of naive epitope-specific CD8+ T cells, researchers reconstructed defined repertoires that could be followed as polyclonal populations during immune responses in vivo.

[BMC Medicine] Scientists conducted a daily longitudinal exact one-to-one matching study based on a set of covariates. They obtained a matched sample of 315,650 individuals aged 18–70 years who received the 3rd dose at 20–30 weeks after the 2nd dose and an equally large control group who did not.

[Cell Host & Microbe] Investigators applied two assays to quantify neutralizing antibody (NAbs) in sera from control, Mpox virus (MPXV)-infected or Modified Vaccinia Ankara (MVA)-vaccinated individuals. Various levels of MVA NAbs were detected after infection, historic smallpox, or recent MVA vaccination.

[Thorax] A comprehensive panel of 63 biomarkers was measured in repeated bronchoalveolar lavage fluid and plasma samples of patients with COVID-19 acute respiratory distress syndrome.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Treatment of HIV-1ADA-infected CD34+ NSG-humanized mice with long-acting ester prodrugs of cabotegravir, lamivudine, and abacavir in combination with native rilpivirine was followed by dual CRISPR-Cas9 C-C chemokine receptor type five (CCR5) and HIV-1 proviral DNA gene editing.