Publication

[Heliyon] Glucocorticoid receptor (GR) expression and its prognosis role were analyzed based on the TCGA dataset. Bioinformatic analysis was performed to identify the candidate of GR downstream, which includes FOXO3a.

[Journal of Biological Chemistry] With in vivo and in vitro ubiquitination assays, OUT domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) was shown to block ubiquitin transfer to YTH domain-containing family protein 2 (YTHDF2) independent of its deubiquitinase activity.

[Cancer Research] The authors identified that expression of adipose triglyceride lipase, an enzyme that controlled lipid droplet homeostasis and a previously suspected tumor suppressor, correlated with worse overall survival in men with advanced CRPC.

[Nature Communications] To improve PDAC therapy, researchers established screening systems based on organoid and co-culture technologies and found a payload of antibody–drug conjugate, a bromodomain and extra-terminal (BET) protein degrader named EBET.

[Cell Reports Medicine] Investigators showed that PRMT1 was highly expressed in murine and human pancreatic cancer and was essential for cancer cell proliferation and tumorigenesis.

[Molecular Cell] Researchers revealed that H2AK119ub1 had two distinct roles in gene expression, through differentially modulating chromatin compaction mediated by canonical polycomb repressive complex 1 (PRC1) and the linker histone H1.