Publication

[Nature Communications] Investigators utilized a panel of 16 serum factors to show that a circulating level of serum amyloid A  > 20.0 mg/L has the highest accuracy in predicting anti-PD-1 resistance in hepatocellular carcinoma.

[eLife] Scientists reported that Sass6‑mutant mouse embryos lack centrioles, activate the mitotic surveillance cell death pathway and arrest at mid‑gestation. In contrast, SAS‑6 is not required for centriole formation in mouse ESCs, but is essential to maintain centriole architecture.

[Stem Cell Research] A human iPSCs line was established from a 4-year-1-month-old girl with subcortical band heterotopia carrying a heterozygous mutation in DCX. The generated iPSC line showed the ability to differentiate into three lineages in vitro and was confirmed by pluripotency markers and the original gene mutation.

[European Respiratory Journal] Researchers determined whether ezetimibe has therapeutic potential against idiopathic pulmonary fibrosis. Primary lung fibroblasts isolated from both humans and mice were employed for mechanistic in vitro experiments.

[Cancer Cell] Scientists identified an intermediate high-plastic cell state marked by the expression of an AST plasticity signature and Krt6a. Notably, expression of the AST plasticity signature and KRT6A at baseline correlates with poor adagrasib responses.

[Hepatology] Scientists determined whether metabolic reprogramming fueled the adaptation and remodeling of cholangiocarcinoma cells to the lymph node microenvironment.