Publication

[Cell Death & Disease] The authors reported that the protein arginine methyltransferase 1 (PRMT1) promoted glycolysis, proliferation, and tumorigenesis in colorectal cancer cells.

[Scientific Reports] Researchers reported that long-term culturing of colonic epithelial organoids generated from stem cells of healthy and diseased individuals resulted in decreased nucleotide element 1 (LINE-1) methylation level, when compared to tissue of origin and short-term cultures.

[Heliyon] Pyrroline-5-carboxylate reductase 1 (PYCR1) expression was manipulated by depletion or overexpression approaches in gastric cancer cells, and these cells were applied to explore the functional roles of PYCR1.

[The Journals of Gerontology: Series A] Scientists revealed that DHCR24 expression was chronologically decreased in senescent HUVECs and the aortas of aged mice.

[Angiogenesis] Researchers showed that C81, a derivative of the plant alkaloid annomontine previously shown to inhibit endothelial inflammation, impeded angiogenesis by inhibiting CDC2-like kinases and WNT/β-catenin signaling.

[Science Of The Total Environment] Scientists investigated the impact of PM2.5 on vascular endothelial cell senescence and to elucidate the underlying mechanisms. Their findings revealed that PM2.5 exposure led to an increase in senescence-associated β-galactosidase activity and the expression of the cell cycle-blocking proteins P53/P21 and P16 in HUVECs.