Publication

[Cell Reports] Investigators found that the level of α-1,2-mannosylated CD133 was associated with the level of stemness genes in intrahepatic cholangiocarcinoma tissues. α-1,2-mannosylated CD133+ cells possessed the characteristics of tumor-initiating cells.

[Cell Reports] Scientists established that ERK5 was a critical regulator of cell proliferation and glycolysis in diffuse midline glioma with altered H3K27.

[Developmental Cell] Investigators identified a role for autophagy in regulating platelet-derived growth factor receptor alpha (PDGFRA) signaling and levels.

[eLife] Researchers probed the decline of B cells in human CTLA-4 knock-in mice by using anti-human CTLA-4 antibody Ipilimumab conjugated to a drug payload emtansine

[eLife] Through biochemical analysis of RNA:protein interactions, investigators uncovered a non-coding RNA circuit regulating activation and differentiation of cytotoxic T cells composed of the long non-coding RNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (Malat1) and the microRNA family miR-15/16.

[Nature Communications] The authors investigated transcriptional heterogeneity in adipose invariant natural killer T cells and their hierarchy using single-cell RNA sequencing in lean and obese mice.