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Extracellular Matrix News
Extracellular Matrix-Trapped Bioinspired Lipoprotein Prolongs Tumor Retention to Potentiate Antitumor Immunity
[Advanced Materials] Researchers designed a protease-activated fibronectin (FN1) and/or tenascin C (TNC) binding peptide (FTF) and propose an ECM-trapped bioinspired lipoprotein that could be preferentially captured by the TNC and/or FN1 for tumor retention, and then be responsively dissociated from the matrix to potentiate the antitumor immunity.
Neural Cell News
Molecular Profiling of Human Substantia Nigra Identifies Diverse Neuron Types Associated with Vulnerability in Parkinson’s Disease
[Science Advances] Investigators identified cell clusters representing various neuron types, glia, endothelial cells, pericytes, fibroblasts, and T cells and investigated cell type–dependent alterations in gene expression in Parkinson's disease.
Hepatic Cell News
A Highly Efficient Cell Culture Method Using Oxygen-Permeable PDMS-Based Honeycomb Microwells Produces Functional Liver Organoids from Human Induced Pluripotent Stem Cell-Derived Carboxypeptidase M Liver...
[Biotechnology And Bioengineering] Investigators developed a highly efficient method for generating functional liver organoids from hiPSC-derived carboxypeptidase M liver progenitor cells, using a microwell structure, and enhanced maturation through direct oxygenation in oxygen-permeable culture plates.
Hepatic Cell News
Investigation of the Effects of T-2 Toxin in Chicken-Derived Three-Dimensional Hepatic Cell Cultures
[Scientific Reports] To gain more accurate understanding, the effects of T-2 toxin were investigated in the present study in chicken-derived 3D primary hepatic cell cultures. 3D spheroids were treated with three concentrations of T-2 toxin for 24 hours.
Mesenchymal Cell News
Umbilical Cord MSC-Derived Exosomes Improve Alveolar Macrophage Function and Reduce Lps-Induced Acute Lung Injury
[Journal Of Cellular Biochemistry] Investigators focused on analyzing the role of umbilical cord MSC-derived exosomes in reducing lipopolysaccharide-induced acute lung injury and investigated the mechanism involved.
Mesenchymal Cell News
Novel Therapeutic Targets, Including IGFBP3, of Umbilical Cord Mesenchymal Stem Cell-Conditioned Medium in Intrauterine Adhesion
[Biology Open] Umbilical cord mesenchymal stem cell conditioned medium produced positive effects on TGF-β induced intrauterine adhesion cell model.