Publication

[Journal Of Clinical Investigation] One of the paradoxes concerning BRCA2 is the fact that its inactivation affects genetic stability and is deleterious for cellular and organismal survival, while BRCA2-mutated cancer cells adapt to this detriment and malignantly proliferate.

[Cell] Investigators systematically tested various culture conditions for establishing monkey naive ESCs and optimized the procedures for chimeric embryo culture.

[American Journal Of Human Genetics] generated an edited c.1222C>T hepatocyte cell line and humanized c.1222C>T mouse models, with which scientists demonstrated efficient in vitro and in vivo correction of the variant with prime editing.

[EMBO Reports] Researchers revealed that lipin-2, a phosphatidic acid phosphatase whose mutations produce an autoinflammatory syndrome known as Majeed syndrome in humans, was regulated by interfeon in a signal transducer and activator of transcription-1-dependent manner.

[Cancer Immunology Research] Investigators performed a metabolic CRISPR/Cas9 screen and pinpointed novel candidate positive and negative metabolic regulators of forkhead box P3.

[Brain Behavior And Immunity] The authors employed chemogenetic manipulation of microglia using the artificial Gi-Dreadd receptor within a kainic acid induced murine seizure model.