Publication

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Escherichia coli strain and indole-3-lactic acid contributed to the relief of colitis by inhibiting the production of epithelial CCL2/7, thereby reducing the accumulation of inflammatory macrophages in vitro and in vivo.

[Nature Immunology] Mechanistically, E-selectin engagement triggered Bruton’s tyrosine kinase-dependent tyrosine phosphorylation of NLRP3.

[Science Immunology] Researchers used bulk and single-cell transcriptomics to analyze expression of transposable elements in subpopulations of mouse and human CD8+ tumor-infiltrating T lymphocytes.

[Nature Cell Biology] Scientists described a unique juxtaposition of caveola clusters and matrix degradative invadosomes at contact sites between the plasma membrane of cancer cells and constricting fibrils both in 2D and 3D type I collagen matrix environments.

[Science Immunology] Thymic epithelial cell (TEC)-specific deletion of Ikzf1 in mice resulted in a profound decrease in Aire+ medullary TECs, a global loss of tissue-specific antigengene expression, and the development of autoimmunity.

[iScience] Investigators characterized the long-term fate and safety of human dorsal spinal γ-aminobutyric acid (GABA) neural progenitor cells (NPCs) in naïve rats over one year. All grafted NPCs had undergone differentiation, yielding mainly neurons and astrocytes.