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Carnitine Acetyltransferase Deficiency Mediates Mitochondrial Dysfunction-Induced Cellular Senescence in Dermal Fibroblasts

[Aging Cell] Carnitine acetyltransferase knockdown caused mitochondrial dysfunction, as indicated by increased oxidative stress, disruption of mitochondrial morphology, and a metabolic shift from oxidative phosphorylation to glycolysis.

MYH10 Activation Rescues Contractile Defects in Arrhythmogenic Cardiomyopathy (ACM)

[Nature Communications] By studying pathogenic deletion mutations in the desmosomal protein plakophilin-2 (PKP2), investigators identified a general mechanism by which PKP2 delocalization restrictED actomyosin network organization and cardiac sarcomeric contraction in arrhythmogenic cardiomyopathy.

Single-Molecule Spatial Transcriptomics of Human Thoracic Aortic Aneurysms Uncovers Calcification-Related CARTPT-Expressing Smooth Muscle Cells

[Arteriosclerosis Thrombosis And Vascular Biology] Single-molecule spatial distribution of transcripts from 140 genes was analyzed in fresh-frozen human thoracic aortic aneurysm samples with region and sex-matched controls.

Cellular Prion Protein Moonlights Vascular Smooth Muscle Cell Fate: Surveilled by Trophoblast Cells

[Journal of Cellular Physiology] Investigators demonstrated that cellular prion was expressed in the rat metrial gland, the entry point of spiral arteries with the highest expression on E16.5, the day at which trophoblast invasion peaked.

Potentiation of Active Force by Cyclic Strain in Sheep Carotid Arterial Smooth Muscle

[Journal Of Applied Phycology] Researchers examined how inhibition of protein kinase C, rho-kinase, and integrin-link kinase affected force potentiation in sheep carotid artery.

Silencing circSERPINE2 Restrains Mesenchymal Stem Cell Senescence via the YBX3/PCNA/p21 Axis

[Cellular And Molecular Life Sciences] RNA sequencing analysis of differentially expressed circular RNAs in long-term-cultured MSCs revealed that circSERPINE2 expression was significantly increased in late passages.

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