Publication

[Nature Communications] Researchers showed that a llama-derived nanobody M4 neutralized multiple GII.4 variants with high potency in human intestinal enteroids.

[Nature Communications] A microfluidic organ-on-a-chip lined by human lung alveolar epithelium interfaced with pulmonary endothelium was used to model acute radiation-induced lung injury in vitro.

[Oncogene] Scientists reported that D-mannose up-regulated lysosomal activity by enhancing TFE3-mediated lysosomal biogenesis, thereby increasing the degradation of epidermal growth factor receptor (EGFR) and significantly down-regulating its protein level.

[Nature Communications] Investigators found that TNFα could induce stemness and activate senescence signaling by enhancing cell plasticity in colonic epithelial cells, which could act as a selective pressure to mutate senescence-related genes in inflammation-associated colonic tumors.

[Journal Of Investigative Dermatology] Glycyl-tRNA synthetase (GARS) was highly expressed in human skin keratinocytes, and GARS knockdown in keratinocytes suppressed cell proliferation and promoted apoptosis via the nuclear factor kappa-B/mitogen-activated protein kinase signaling pathway.

[Aging Cell] Carnitine acetyltransferase knockdown caused mitochondrial dysfunction, as indicated by increased oxidative stress, disruption of mitochondrial morphology, and a metabolic shift from oxidative phosphorylation to glycolysis.