Publication

[Cell Death Discovery] Scientists demonstrated that Osimertinib induced paraptosis in glioblastoma cells, as evidenced by the formation of cytoplasmic vacuoles, accumulation of ubiquitinated proteins, and upregulation of endoplasmic reticulum stress markers like CHOP.

[International Journal of Oncology] Researchers determined whether coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) plays a functional role in U87 glioblastoma cells expressing the constitutively active epidermal growth factor receptor variant III.

[Brain Structure & Function] Investigators provided evidence implicating midbrain dopamine neurons in the innervation of oligodendrocyte lineage cells in the anterior corpus callosum and nearby white matter tracts of male and female adult mice.

[Brain Research Bulletin] The authors investigated the potential of recombinant human FGF21 in inhibiting ferroptosis of nerve cells and improving limb function after spinal cord injury, along with its underlying mechanisms.

[Emerging Microbes & Infections] Investigators conceptualized a novel mRNA-based multi-antigen influenza vaccine consisting of three conserved antigens of influenza A virus, including the ectodomain of the M2 ion channel, the long alpha-helix of haemagglutinin stalk region, and nucleoprotein.

[Journal Of Infectious Diseases] Researchers demonstrated that THP-1 monocytes and SupT1 T-cells exposed to Ebola virus (EBOV) undergo pyroptosis and necroptosis, respectively, through direct contact with EBOV, and also mediated pyroptosis or necroptosis of uninfected bystander cells via indirect effects associated with secreted soluble factors.