Review

[Blood Cancer Journal] Inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio, are associated with the aggressiveness of polycythemia vera and essential thrombocythemia, linking thrombosis to second cancers risk.

[Nature Reviews Cancer] Scientists focus on advancements in understanding how CSCs in solid tumours achieve their unique immune-evasive properties, enabling them to drive tumor regrowth.

[Neuro-Oncology] Scientists discuss the basics and scientific considerations for CAR T-cell therapies and highlight recent clinical trials.

[Nature Reviews Drug Discovery] Scientists assess TNF superfamily-targeted biologics currently in clinical development for immune system-related diseases, highlighting ongoing challenges and future directions.

[Journal of Experimental Medicine] The authors discuss recent findings regarding the origin and regulation of mucosal-associated invariant T (MAIT) ligands and the role of MAIT cells in barrier tissues.

[Journal of Hepatology] The most advanced compound, resmetirom, is an oral drug that demonstrated, in a large Phase III trial in MASH patients, the ability to remove liver fat, reduce aminotransferase levels and improve atherogenic dyslipidemia with a good tolerability profile.