Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages

Scientists summarize the roles and mechanisms of exosomes in the interaction between tumor cells and macrophages and the potential methods by which exosomes are used to target the communication between tumor cells and macrophages to treat cancer.
[Molecular Therapy]
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The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

Investigators summarize and question what is known and remains to be discovered about the TREM2 signaling pathway, track the consequences of its activation in physiological niches and pathological contexts, and highlight the promising potential of therapeutic manipulation of TREM2 signaling.
[Cell]
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Old Dogs, New Trick: Classic Cancer Therapies Activate cGAS

The authors review the antitumor roles of the GMP-AMP synthase (cGAS-STING) pathway during tumorigenesis, cancer immune surveillance, and cancer therapies. They also highlight classic cancer therapies that elicit antitumor immune responses through cGAS activation.
[Cell Research]
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Skull Base Chordomas and Chondrosarcomas

Chordomas and chondrosarcomas are not sensitive to chemotherapy and there are no approved drugs for their treatment. The present treatment concept is a combination of surgical resection with a maximal excision and preserving patients’ quality of life by adjuvant radiotherapy for both, chordomas and chondrosarcomas.
[Neuroendocrinology]
Kremenevski, N., Schlaffer, S.-M., Coras, R., Kinfe, T. M., Graillon, T., & Buchfelder, M. (2020). Skull base chordomas and chondrosarcomas. Neuroendocrinology. https://doi.org/10.1159/000509386 Cite
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Enteroendocrine Dynamics – New Tools Reveal Hormonal Plasticity in the Gut

Researchers analyzed advantages and disadvantages of novel in vitro tools, adult stem cell or iPS-derived intestinal organoids, that have been crucial for recent findings on enteroendocrine development and plasticity.
[Endocrine Reviews]
Beumer, J., Gehart, H., & Clevers, H. (n.d.). Enteroendocrine dynamics – New tools reveal hormonal plasticity in the gut. Endocrine Reviews. https://doi.org/10.1210/endrev/bnaa018 Cite
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Nanotechnology for Angiogenesis: Opportunities and Challenges

The authors summarize nanotechnology-based strategies that have been explored in the broad area of angiogenesis. Lipid-based, carbon-based and polymeric nanoparticles, and a wide range of inorganic and metallic nanoparticles are covered in detail.
[Chemical Society Reviews]
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Pre-Clinical Modeling of Cutaneous Melanoma

The authors discuss the current available repertoire of melanoma models including two- and three-dimensional tissue cultures, organoids, genetically engineered mice and patient-derived xenograft.
[Nature Communications]
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Mitochondria in Skin Health, Aging, and Disease

Scientists discuss the essential role of mitochondria in regulating normal and abnormal skin physiology and the possibility of targeting this organelle in various skin disorders.
[Cell Death & Disease]
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MicroRNAs in Hematopoietic Stem Cell Aging

The authors discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.
[Mechanisms of Ageing and Development]
Luinenburg, D. G., & de Haan, G. (2020). MicroRNAs in Hematopoietic Stem Cell Aging. Mechanisms of Ageing and Development, 111281. https://doi.org/10.1016/j.mad.2020.111281 Cite
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Advances in the Development of Gene Therapy, Noncoding RNA, and Exosome‐Based Treatments for Tendinopathy

The authors summarize the current understanding and treatments for tendinopathy. They also highlight recent advances in gene therapy, the potential of noncoding RNAs, such as microRNAs, and exosomes, which are nanometer‐sized extracellular vesicles secreted from cells, for the treatment of tendinopathy.
[Annals of the New York Academy of Sciences]
Ilaltdinov, A. W., Gong, Y., Leong, D. J., Gruson, K. I., Zheng, D., Fung, D. T., Sun, L., & Sun, H. B. (n.d.). Advances in the development of gene therapy, noncoding RNA, and exosome-based treatments for tendinopathy. Annals of the New York Academy of Sciences, n/a(n/a). https://doi.org/10.1111/nyas.14382 Cite
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The Role of B Cells in Heart Failure and Implications for Future Immunomodulatory Treatment Strategies

B cells produce antibodies that interfere with cardiomyocyte function, which culminates as the result of recruitment and activation of a variety of innate and structural cell populations, including neutrophils, macrophages, fibroblasts, and T cells.
[ESC Heart Failure]
García‐Rivas, G., Castillo, E. C., Gonzalez‐Gil, A. M., Maravillas‐Montero, J. L., Brunck, M., Torres‐Quintanilla, A., Elizondo‐Montemayor, L., & Torre‐Amione, G. (n.d.). The role of B cells in heart failure and implications for future immunomodulatory treatment strategies. ESC Heart Failure, n/a(n/a). https://doi.org/10.1002/ehf2.12744 Cite
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