Review

[Nature Biotechnology] By leveraging powerful DNA-targeting technologies, such as CRISPR, epigenome editing exploited the heritable and reversible mechanisms of epigenetics to alter gene expression without introducing DNA breaks, inducing DNA damage or relying on DNA repair pathways.

[Trends in Cell Biology] The authors discuss recent evidence suggesting that NADPH generated in the mitochondria can influence the fate of HSCs. Although NADPH has multiple functions, HSCs show high levels of NADPH that are preferentially used for cholesterol biosynthesis.

[BioEssays] The authors review the recent evidence of the cis-regulatory transposable elements in normal development and malignancy as well as the key transcription factors and regulatory pathways that are implicated in both cell states.

[Cell Communication and Signaling] Scientists review recent studies on axonal mitophagy and summarize the progress of research on axonal mitophagy in optic nerve-related diseases to provide insights into diseases associated with axonal damage in optic ganglion cells.

[Biomaterials Science] Scientists summarize the recent advances in various nanozymes for Alzheimer's disease diagnosis and therapy, including with peroxidase-like-activity gold nanozymes, iron nanozymes, superoxide dismutase-like- and catalase-like-activity selenium dioxide nanozymes, platinum nanozymes, and peroxidase-like palladium nanozymes, among others.

[Expert Review of Vaccines] The authors report advances in understanding the mode of action of AS01 that contributed to the development of efficacious vaccines preventing disease due to malaria, herpes zoster, and respiratory syncytial virus.