Review

[Stem Cell Reviews And Reports] The authors summarize the status of MSC transplantation in treating liver diseases, focusing on the therapeutic mechanisms, including differentiation into hepatocyte-like cells, immunomodulating function with a variety of immune cells, paracrine effects via the secretion of various cytokines and extracellular vesicles, and facilitation of homing and engraftment.

[Trends In Molecular Medicine] When stress conditions are restrained, and tumor microenvironment becomes beneficial, quiescent cancer cells re-enter cell cycle to facilitate tumor spread and cancer progression/metastasis. Recent studies have highlighted the dynamic role of regulatory non-coding RNAs (ncRNAs) in orchestrating cancer quiescence.

[Trends In Cancer] T cells engineered with mutant (m)KRAS-specific T cell receptors have already shown early clinical promise, and next-generation mKRAS vaccines are being studied. As this emerging field rapidly develops, scientists suggest that a significant component in ‘drugging KRAS’ may be immunological.

[Experimental & Molecular Medicine] The authors focus on the causes and implications of β-cell failure, as well as its potential reversibility as a type 2 diabetes treatment.

[Nature Reviews Drug Discovery] Scientists review common targets, current treatments, and emerging therapies for the treatment of five major type 2 chronic inflammatory diseases.

[Disease Models & Mechanisms] Transposable elements play a role in hematopoiesis, especially during periods of high cellular plasticity, such as development, regeneration and aging.