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Mechanisms of Resistance and Treatment of Relapse After CAR T-Cell Therapy for Large B-Cell Lymphoma and Multiple Myeloma

[Transplantation And Cellular Therapy] Focusing on both large B-cell lymphoma and multiple myeloma, investigators review resistance mechanisms, explore therapeutic avenues to overcome resistance to CAR T-cell therapies, and discuss the management of patients who have relapsed after CAR T-cell therapy.

Tissue Engineering Modalities in Skeletal Muscles: Focus on Angiogenesis and Immunomodulation Properties

[Stem Cell Research & Therapy] The authors highlight recent advances in muscle tissue engineering with a focus on recent strategies related to the regulation of vascularization and immune system response at the site of injury.

Noncoding RNAs in Asthmatic Airway Smooth Muscle Cells

[European Respiratory Review] Investigators present a schematic that illustrates the role of ncRNAs in pathophysiological changes to ASMCs that may be useful in future research in diagnostic and treatment strategies for patients with asthma.

Hydrogels and Bioprinting in Bone Tissue Engineering: Creating Artificial Stem-Cell Niches for In Vitro Models

[Advanced Materials] The authors highlight challenges in recapitulating the biological complexity seen in bone and how synergistic application of dynamic hydrogels and innovative bioprinting pipelines could address these challenges to achieve bone models.

Pathological Angiogenesis: Mechanisms and Therapeutic Strategies

[Angiogenesis] Investigators provide an overview of recent insights into blood vessel development and highlight novel therapeutic strategies that promote or inhibit the process of angiogenesis to stabilize, reverse, or even halt disease progression.

IL-12 and IL-23 Pathway Inhibition in Inflammatory Bowel Disease

[Nature Reviews Gastroenterology & Hepatology] The authors provide a summary of the biology of the interleukin (IL)-12 family cytokines IL-12 and IL-23, discuss the role of these cytokines in intestinal homeostasis and inflammation, and highlight IL-12- and IL-23-directed drug development for the treatment of Crohn’s disease and ulcerative colitis.

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