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In Vitro Simulation of the Acute Lymphoblastic Leukemia Niche: A Critical View on the Optimal Approximation for Drug Testing

[Journal of Leukocyte Biology] Investigators discuss in detail cell-to-cell interactions in the two leukemic niches, more explored bone marrow and less studied extramedullary adipose tissue.

Progression of Pre-Rheumatoid Arthritis to Clinical Disease of Joints: Potential Role of Mesenchymal Stem Cells

[Life Sciences] There still exists a gap in the early phase of Rheumatoid arthritis pathogenesis, i.e., the progression of diseases from the systemic circulation to joints. The lack of better understanding of these events results in the inability to answer questions about why only after a certain point of time the disease appears in joints and why in some cases, it simply remains latent and doesn't affect joints at all.

MicroRNAs-Mediated Regulation of the Differentiation of Dental Pulp-Derived Mesenchymal Stem Cells: A Systematic Review and Bioinformatic Analysis

[Current Stem Cell Research & Therapy] The findings of this systematic review support the potential application of the specific miRNAs to regulate the directed differentiation of hDP-MSCs in the field of regenerative therapies.

Induction and Application of Human Naive Pluripotency

[Cell Reports] Investigators discuss their applications in studies of regulatory mechanisms involved in early developmental processes, including identification of molecular features, X chromosome inactivation modeling, transposable elements regulation, metabolic characteristics, and cell fate regulation.

Cells of the Tumor Microenvironment Speak the Wnt Language

[Trends In Molecular Medicine] The authors summarize the evidence that not only multiple cancer cell types, but also cells constituting the tumor microenvironment ‘speak the Wnt language’.

Novel Strategy for Oncogenic Alteration-Induced Lipid Metabolism Reprogramming in Pancreatic Cancer

[Acta Biochimica et Biophysica Sinica] Scientists focus on the mechanisms regulating lipid metabolism reprogramming in pancreatic cancer cells to provide new therapeutic targets and aid the development of new therapeutic strategies for pancreatic cancer.

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