Review

[Advanced Healthcare Materials] Scientists summarize recent progress in engineering approaches, key components, and culture platforms for tissue-engineered human microvessel models.

[Neuro-Oncology] Investigators present the integrative paired single-cell RNA-seq analysis of 76 tumor samples from patients in a clinical trial of the PD-1 inhibitor nivolumab and untreated patients.

[Trends In Endocrinology And Metabolism] The authors describe recent findings from clinical trials, observational studies of human patients, and animal studies on the impact of the microbiome on the efficacy of immune checkpoint blockade.

[Basic Research In Cardiology] Investigators provide an overview of current knowledge on cell cycle regulation and mechanisms underlying cardiomyocyte proliferation in cases of heart failure.

[Molecular Pharmaceutics] The authors clarified the feasibility and potential of Treg-derived extracellular vesicles (Treg-EVs) in diseases and theranostics, facilitating further research and application of Treg-EVs.

[iScience] The authors discuss how therapeutically targeting YAP through YAP inhibitors verteporfin and celastrol and its downstream mediators CCN1 and CCN2 might be useful in treating melanoma.