Review

[Clinical & Experimental Metastasis] The authors critically review the current implications of liquid biopsy, with special focus on circulating tumor cells, and describe the hurdles that need to be addressed before liquid biopsy can be implemented in clinical standard of care guidelines.

[Molecular Neurobiology] The authors discuss the current knowledges about the vital and dual roles of astrocytes and microglia on the blood–brain barrier breakdown during ischemic stroke.

[Endocrine-Related Cancer] Scientists provide descriptions of bioengineered 3D tumor models, such as organoids and tumor-on-a-chip systems, focusing on thyroid, adrenal, and neuroendocrine tumors and how they have been and are being applied in the context of endocrine tumors.

[Stroke and Vascular Neurology] The authors introduce the current or promising recombinant proteins for thrombolysis therapy in ischemic stroke and highlight the promise and challenges of stem cells and cerebral organoids in stroke therapy.

[Molecular Therapy] The authors summarize current clinical trials of antitumor NK cell therapy, provide an overview of innovative strategies for reprogramming NK cells, and also discuss some potential combination therapies.

[Bjog-An International Journal Of Obstetrics And Gynaecology] The authors identify the changes in the ECM in pelvic organ prolapse patients as studies on still controversial.