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Fatty Acid Metabolism of Immune Cells: A New Target of Tumor Immunotherapy

[Cell Death Discovery] In the face of the current situation of poor therapeutic effects of tumor immunotherapy, combined application of targeted immune cell fatty acid metabolism seems to have good therapeutic potential, which is blocked at immune checkpoints.

Metabolic Waypoints during T Cell Differentiation

[Nature Immunology] The authors discuss how T cells integrate nutrient sensing with activating stimuli to shape their differentiation and sensitivity to metabolites.

Stem Cell-Based Therapy in Cardiac Repair after Myocardial Infarction: Promise, Challenges, and Future Directions

[Journal of Molecular and Cellular Cardiology] Scientists summarize the research progress on the mechanisms and challenges of mesenchymal stromal cells and induced pluripotent stem cell-derived cardiomyocytes in post-MI heart repair.

Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases

[Journal Of Investigative Dermatology] The authors summarize the current update on IL-36 cytokines in inflammatory skin diseases.

The Role of Endothelial Cell-Pericyte Interactions in Vascularization and Diseases

[Journal Of Advanced Research] The authors explore the diverse roles of endothelial cells and pericytes in the formation and reshaping of blood vessels. This review focused on the essential signaling pathways that facilitate communication between these cells and investigated how disruptions in these pathways may contribute to disease.

Engineering Approaches for RNA-Based and Cell-Based Osteoarthritis Therapies

[Nature Reviews Rheumatology] Investigators highlight emerging classes of RNA-based technologies that hold potential for osteoarthritis therapies, including small interfering RNA for gene silencing, microRNA and anti-microRNA for multi-gene regulation, mRNA for gene supplementation, and RNA-guided gene-editing platforms such as CRISPR–Cas9.

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