Review

[Nature Cardiovascular Research] Combinations of endothelin receptor blockers with other drugs, including phosphodiesterase-5 inhibitors and sodium–glucose co-transporter-2 antagonists, may drive synergistic benefits with the prospect of alleviating side effects.

[Trends In Biotechnology] The authors review recent developments in cancer-on-chip models, focusing on three main TME components: (i) the anisotropic ECM architectures, (ii) the vasculature, and (iii) the immune system.

[Stem Cell Reviews And Reports] Investigators explored novel avenues of research that delve into the distinctive characteristics of CSCs within their surrounding tumor microenvironment.

[Annals of Hematology] Recent research has suggested that activating transcription factor 4 contributes to decreased fetal hemoglobin level through its binding to potent negative regulators of HbF, such as BCL11A and MYB.

[Nature Reviews Drug Discovery] The authors summarize the resistance mechanisms to CAR-T cell immunotherapy by analysing CAR-T cell dysfunction, intrinsic tumor resistance, and the immunosuppressive tumor microenvironment.

[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors summarize published data that reveal Snail proteins not only as key inducers of the EMT in ovarian cancer but also as crucial links between the acquisition of ovarian cancer stem properties and spheroid formation.