ulcerative colitis

[International Immunopharmacology] The authors explored the protective effect and preliminary mechanism of Dioscin on dextran sulfate sodium (DSS)-induced colitis in mice and showed that Dioscin reduced DSS-induced disease activity index increase, colon length shortening and colon pathological damage.

[Inflammatory Bowel Diseases] Investigators profiled a panel of 39 genes potentially involved in cancer predisposition and searched for germline variants in IBD patients with colorectal cancer or high-grade dysplasia.

[Immunity] Scientists examined the immunological features and metabolic microenvironment of untreated individuals with inflammatory bowel disease by multiomics analyses.

[Mucosal Immunology] The authors evaluate the mechanistic underpinnings of murine models of Crohn's disease-ileitis, discuss their phenotypic similarities to human disease, and envisage their further exploitation for the development of novel targeted and personalized therapeutics.

[Science Translational Medicine] The authors reported the discovery of an intrinsic counter regulatory mechanism in colitis pathogenesis that may be targeted for inflammatory bowel disease treatment.

[Scientific Reports] Scientists investigated if remodeling of the intestinal basement membrane type VI collagen was associated with pathophysiological changes in Crohn’s disease and ulcerative colitis.