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western blot analysis

Clock-Modified Mesenchymal Stromal Cells Therapy Rescues Molecular Circadian Oscillation and Age-Related Bone Loss via miR142-3p/Bmal1/YAP Signaling Axis

[Cell Death Discovery] Proliferation capability, osteogenic lineage commitment, senescence-associated secreted phenotype and circadian oscillation of clock genes under osteogenic condition were assessed in bone marrow MSCs from young adult and aged adult mice.

Hepatoprotective Effects of Sevoflurane against Hepatic Ischemia-Reperfusion Injury by Regulating microRNA-124-3p-Mediated TRAF3/CREB Axis

[Cell Death Discovery] Scientists defined the role of sevoflurane in hepatic ischemia-reperfusion injury as well as its underlying mechanism.

Prenatal Exposure to Triphenyl Phosphate Activated PPARγ in Placental Trophoblasts and Impaired Pregnancy Outcomes

[Environmental Pollution] Using placental trophoblast cell line JEG-3, the authors demonstrated that triphenyl phosphate could induce endoplasmic reticulum stress and cell apoptosis through PPARγ-mediated lipid metabolism.

Dual-sgRNA CRISPR/Cas9 Knockout of PD-L1 in Human U87 Glioblastoma Tumor Cells Inhibits Proliferation, Invasion, and Tumor-Associated Macrophage Polarization

[Scientific Reports] Utilizing dual-single guide RNAs (sgRNAs) and a homology-directed repair template with the CRISPR/Cas9 gene-editing system is a promising avenue for the treatment of glioblastoma multiforme.

Silencing of LINC01963 Enhances the Chemosensitivity of Prostate Cancer Cells to Docetaxel by Targeting the miR-216b-5p/TrkB Axis

[Laboratory Investigation] Silencing LINC01963 inhibited TrkB protein level to enhance the chemosensitivity of PC3-DR to docetaxel by means of competitively binding to miR-216b-5p.

Apoptosis Induction in Human Lung and Colon Cancer Cells via Impeding VEGF Signaling Pathways

[Molecular Biology Reports] Researchers assessed the suppressing effect of VGB4, a vascular endothelial growth factor (VEGF) antagonist peptide with the binding ability to both VEGF receptor1 and VEGF receptor2, on VEGF-induced proliferation and migration of the human lung adenocarcinoma cell line A549 and the human colon adenocarcinoma cell line HT29.

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