Neuron Specific Enolase Promotes Tumor Metastasis by Activating the Wnt/β-Catenin Pathway in Small Cell Lung Cancer

Investigators clarified the role of neuron-specific enolase (NSE) in the progression of SCLC and found that NSE expression was positively correlated with distant metastasis.
[Translational Oncology]
Zha, Z., Li, D., Zhang, P., Wang, P., Fang, X., Liu, X., Weng, C., Li, B., Wu, Y., Mao, H., Wang, L., Xu, L., Dong, J., Guan, M., Lu, L., & Liu, G. (2021). Neuron specific enolase promotes tumor metastasis by activating the Wnt/β-catenin pathway in small cell lung cancer. Translational Oncology, 14(4), 101039. https://doi.org/10.1016/j.tranon.2021.101039 Cite
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Role of Adenomatous Polyposis Coli in Proliferation and Differentiation of Colon Epithelial Cells in Organoid Culture

Researchers performed genetic analyses of adenomatous polyposis coli using a 3D organoid culture of mouse colon epithelia, which enabled the detailed examination of epithelial properties.
[Scientific Reports]
Yamazaki, D., Hashizume, O., Taniguchi, S., Funato, Y., & Miki, H. (2021). Role of adenomatous polyposis coli in proliferation and differentiation of colon epithelial cells in organoid culture. Scientific Reports, 11(1), 3980. https://doi.org/10.1038/s41598-021-83590-6 Cite
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The miR-181a-SFRP4 Axis Regulates Wnt Activation to Drive Stemness and Platinum Resistance in Ovarian Cancer

Using a miRNA sensor-based approach, scientists identified miR-181a as a novel driver of Wnt/β-catenin signaling. miR-181ahigh primary HGSOC cells exhibited increased Wnt/β-catenin signaling, which was associated with increased stem-cell frequency and platinum resistance.
[Cancer Research]
Nagaraj, A. B., Knarr, M., Sekhar, S., Connor, R. S., Joseph, P., Kovalenko, O., Fleming, A., Surti, A., Nurmemmedov, E., Beltrame, L., Marchini, S., Kahn, M., & DiFeo, A. (2021). The miR-181a-SFRP4 axis regulates Wnt activation to drive stemness and platinum resistance in ovarian cancer. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2041 Cite
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Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells

Scientists evaluated the effects of myristoleic acid on anagen-activating signaling pathways in dermal papilla cells.
[Biomolecules & Therapeutics]
Choi, Y. K., Kang, J.-I., Hyun, J. W., Koh, Y. S., Kang, J.-H., Hyun, C.-G., Yoon, K.-S., Lee, K. S., Lee, C. M., Kim, T. Y., Yoo, E.-S., & Kang, H.-K. (n.d.). Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells. Biomolecules & Therapeutics. https://doi.org/10.4062/biomolther.2020.169 Cite
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Zeb1 Serves An Oncogenic Role In The Tumorigenesis Of HCC By Promoting Cell Proliferation, Migration, And Inhibiting Apoptosis Via Wnt/β-catenin Signaling Pathway

Scientists demonstrated that the expression level of ZEB1 was significantly elevated both in liver tissues of hepatocellular carcinoma (HCC) patients and cell lines. Moreover, ZEB1 could promote the proliferation, migration, and invasion of HCC cells.
[Acta Pharmacologica Sinica]
Li, L., Yang, J., Rong, F., Luo, Z., Hu, S., Fang, H., Wu, Y., Yao, R., Kong, W., Feng, X., Chen, B., Li, J., & Xu, T. (2021). ZEB1 serves an oncogenic role in the tumourigenesis of HCC by promoting cell proliferation, migration, and inhibiting apoptosis via Wnt/β-catenin signaling pathway. Acta Pharmacologica Sinica, 1–14. https://doi.org/10.1038/s41401-020-00575-3 Cite
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Mesenchymal Stem Cell-Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells Into Dormancy at the Bone Marrow Perivascular Region

Investigators addressed the early period of dormancy when breast cancer cells entered bone marrow at the perivascular region to begin the transition into cancer stem cells, which they proposed as the final step in dormancy.
[Cancer Research]
Sandiford, O. A., Donnelly, R. J., El-Far, M., Burgmeyer, L. M., Sinha, G., Pamarthi, S. H., Sherman, L. S., Ferrer, A. I., DeVore, D. E., Patel, S. A., Naaldijk, Y., Alonso, S., Barak, P., Bryan, M., Ponzio, N. M., Narayanan, R., Etchegaray, J.-P., Kumar, R., & Rameshwar, P. (2021). Mesenchymal stem cell-secreted extracellular vesicles instruct stepwise dedifferentiation of breast cancer cells into dormancy at the bone marrow perivascular region. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2434 Cite
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Farnesyl Dimethyl Chromanol Targets Colon Cancer Stem Cells and Prevents Colorectal Cancer Metastasis

Investigators provided the first demonstration that farnesyl dimethyl chromanol inhibited colon cancer stem cell viability, survival, self-renewal, pluripotent transcription factors expression, organoids formation, and Wnt/β-catenin signalling, as evidenced by comparisons with vehicle-treated controls.
[Scientific Reports]
Wijshake, T., Zou, Z., Chen, B., Zhong, L., Xiao, G., Xie, Y., Doench, J. G., Bennett, L., & Levine, B. (2021). Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin. Proceedings of the National Academy of Sciences, 118(5). https://doi.org/10.1073/pnas.2020478118 Cite
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miR-541-3p Enhances the Radiosensitivity of Prostate Cancer Cells by Inhibiting HSP27 Expression and Downregulating β-Catenin

Scientists investigated the function and mechanism underlying how miR-541-3p modulates the radiosensitivity of prostate cancer cells by regulating HSP27.
[Cell Death Discovery]
He, Z., Shen, F., Qi, P., Zhai, Z., & Wang, Z. (2021). miR-541-3p enhances the radiosensitivity of prostate cancer cells by inhibiting HSP27 expression and downregulating β-catenin. Cell Death Discovery, 7(1), 1–13. https://doi.org/10.1038/s41420-020-00387-8 Cite
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MicroRNA Regulation of Cancer Stem Cells in the Pathogenesis of Breast Cancer

Investigators summarize the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the breast cancer stem cell maintenance.
[Cancer Cell International]
Niu, T., Zhang, W., & Xiao, W. (2021). MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer. Cancer Cell International, 21(1), 31. https://doi.org/10.1186/s12935-020-01716-8 Cite
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E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling

E7386 demonstrated clear antitumor activity via modulation of the Wnt/β-catenin signal pathway and alteration of the tumor and immune microenvironments, and its antitumor activity could be enhanced in combination with anti-PD-1 antibody.
[Cancer Research]
Yamada, K., Hori, Y., Inoue, S., Yamamoto, Y., Iso, K., Kamiyama, H., Yamaguchi, A., Kimura, T., Uesugi, M., Ito, J., Matsuki, M., Nakamoto, K., Harada, H., Yoneda, N., Takemura, A., Kushida, I., Wakayama, N., Kubara, K., Kato, Y., … Ozawa, Y. (2021). E7386, a selective inhibitor of the interaction between β-catenin and CBP, exerts antitumor activity in tumor models with activated canonical Wnt signaling. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0782 Cite
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The Epigenetic Regulator Mll1 Is Required for Wnt-Driven Intestinal Tumorigenesis and Cancer Stemness

Investigators identified the histone methyltransferase Mll1 as a regulator of Wnt-driven intestinal cancer. Mll1 is highly expressed in Lgr5+ stem cells and human colon carcinomas with increased nuclear β-catenin.
[Nature Communications]
Grinat, J., Heuberger, J., Vidal, R. O., Goveas, N., Kosel, F., Berenguer-Llergo, A., Kranz, A., Wulf-Goldenberg, A., Behrens, D., Melcher, B., Sauer, S., Vieth, M., Batlle, E., Stewart, A. F., & Birchmeier, W. (2020). The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness. Nature Communications, 11(1), 6422. https://doi.org/10.1038/s41467-020-20222-z Cite
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