Bortezomib Potentiates Antitumor Activity of Mitoxantrone through Dampening Wnt/β-Catenin Signal Pathway in Prostate Cancer Cells

Researchers determined the anticancer effects of a combination of bortezomib and mitoxantrone by apoptosis and proliferation assay in vivo and in vitro.
[BMC Cancer]
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LINC00662: A New Oncogenic lncRNA with Great Potential

LINC00662 can reduce the promoter methylation level of s-adenosylmethionine-dependent hepatocellular carcinoma-promoting genes by regulating the MAT1A/SAM and AHCY/SAH axes, thereby promoting the activation of oncogenes. Scientists summarize the molecular regulation mechanism of LINC00662.
[Journal of Cellular Physiology]
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An SETD1A/Wnt/β-Catenin Feedback Loop Promotes NSCLC Development

Researchers found that SETD1A positively regulated the Wnt/β-catenin pathway via interacting with and stabilizing β-catenin.
[Journal of Experimental & Clinical Cancer Research]
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Pyrvinium Pamoate Regulates MGMT Expression through Suppressing the Wnt/β-Catenin Signaling Pathway to Enhance the Glioblastoma Sensitivity to Temozolomide

Investigators found that pyrvinium pamoate (PP) and Temozolomide (TMZ) had synergistic effect on inhibiting the viability of glioblastoma multiforme (GBM) cells, and PP induced inhibition of MGMT and enhanced the TMZ chemosensitivity of GBM cells through down-regulating Wnt/β-catenin pathway.
[Cell Death Discovery]
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Transmembrane Protein 97 Exhibits Oncogenic Properties via Enhancing LRP6-Mediated Wnt Signaling in Breast Cancer

Researchers revealed that transmembrane protein 97 was a positive modulator of canonical Wnt signaling which was implicated in the tumorigenesis of breast cancer.
[Cell Death & Disease]
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Exosomal OTULIN from M2 Macrophages Promotes the Recovery of Spinal Cord Injuries via Stimulating Wnt/β-Catenin Pathway-Mediated Vascular Regeneration

Researchers determined that M2-Exos could augment the angiogenic activities of spinal cord microvascular endothelial cells in vitro.
[Acta Biomaterialia]
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Long Noncoding RNA DLGAP1-AS2 Facilitates Wnt1 Transcription through Physically Interacting with Six3 and Drives the Malignancy of Gastric Cancer

Findings demonstrated that DLGAP1-AS2 was significantly up-regulated in gastric cancer (GC) and its high expression was associated with poor prognosis, suggesting that DLGAP1-AS2 might be a putative oncogenic lncRNA of GC. Loss of DLGAP1-AS2 restricted cell proliferation, migration, and invasion in GC cell lines.
[Cell Death Discovery]
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STRAP is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis through a Feed-Forward Mechanism

The authors generated Strap intestinal epithelial knockout mice by crossing mice containing floxed alleles of Strap with Villin-Cre mice. They used human colon cancer cell lines and human and mouse colon tumor-derived organoids for STRAP knockdown/knockout and overexpression experiments.
[Gastroenterology]
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Exosomal MicroRNA-19b Targets FBXW7 to Promote Colorectal Cancer Stem Cell Stemness and Induce Resistance to Radiotherapy

The regulatory role of miR-19b in colorectal cancer stem cells and radiotherapy-resistant cells was determined using miRNA microarray analysis, and its prognostic value was probed using the TCGA database.
[Kaohsiung Journal of Medical Sciences]
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Cardiomyocyte-Specific Deletion of β-Catenin Protects Mouse Hearts from Ventricular Arrhythmias after Myocardial Infarction

The authors demonstrated that entricular tachycardias susceptibility in the chronic phase after myocardial infarction was reduced in mice with cardiomyocyte-specific β-catenin deletion primarily through attenuated structural remodeling, but not ion channel gene alterations.
[Scientific Reports]
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Deciphering the Minimal Quantity of Mouse Primary Cells to Undergo Nephrogenesis Ex Vivo

The authors investigated the ability of renal organoids to undergo nephrogenesis upon Wnt/ β-catenin pathway – mediated tubule induction with a GSK-3 inhibitor or by initiation through the ureteric bud.
[Developmental Dynamics]
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