EGF and BMPs Govern Differentiation and Patterning in Human Gastric Glands

Investigators showed that EGF was the major fate determinant distinguishing the surface and inner part of human gastric glands.
[Gastroenterology]
Wölffling, S., Daddi, A. A., Imai-Matsushima, A., Fritsche, K., Goosmann, C., Traulsen, J., Lisle, R., Schmid, M., Reines-Benassar, M. del M., Pfannkuch, L., Brinkmann, V., Bornschein, J., Malfertheiner, P., Ordemann, J., Link, A., Meyer, T. F., & Boccellato, F. (2021). EGF and BMPs govern differentiation and patterning in human gastric glands. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2021.04.062 Cite
AbstractFull ArticlePress Release
Bookmark

No account yet? Register

0
Share

EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma

Researchers established two sorafenib-resistant, patient-derived tumor xenografts (PDX) that mimicked development of acquired resistance to sorafenib in HCC patients.
[Cancer Research]
Leung, H.-W., Leung, C. O.-N., Lau, E. Y., Chung, K. P. S., Mok, E. H., Lei, M. M. L., Leung, R. W. H., Tong, M., Keng, V. W., Ma, C., Zhao, Q., Ng, I. O.-L., Ma, S., & Lee, T. K. (2021). EPHB2 activates β-catenin to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-21-0184 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Principles of Signaling Pathway Modulation for Enhancing Human Naive Pluripotency Induction

Scientists devised enhanced conditions that enabled stabilization of hPSCs with stringent naive functional and molecular properties while preserving cell-autonomous differentiation competence into embryonic, germ cell and extra-embryonic lineages.
[Cell Stem Cell]
Bayerl, J., Ayyash, M., Shani, T., Manor, Y. S., Gafni, O., Massarwa, R., Kalma, Y., Aguilera-Castrejon, A., Zerbib, M., Amir, H., Sheban, D., Geula, S., Mor, N., Weinberger, L., Tassa, S. N., Krupalnik, V., Oldak, B., Livnat, N., Tarazi, S., … Hanna, J. H. (2021). Principles of signaling pathway modulation for enhancing human naive pluripotency induction. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.04.001 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma

Scientists established two sorafenib-resistant, patient-derived tumor xenografts that mimicked development of acquired resistance to sorafenib in hepatocellular carcinoma patients.
[Cancer Research]
Leung, H.-W., Leung, C. O.-N., Lau, E. Y., Chung, K. P. S., Mok, E. H., Lei, M. M. L., Leung, R. W. H., Tong, M., Keng, V. W., Ma, C., Zhao, Q., Ng, I. O.-L., Ma, S., & Lee, T. K. (2021). EPHB2 activates β-catenin to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-21-0184 Cite
Abstract
Bookmark

No account yet? Register

0
Share

KDM3B-ETF1 Fusion Gene Downregulates LMO2 via the WNT/β-Catenin Signaling Pathway, Promoting Metastasis of Invasive Ductal Carcinoma

Scientists investigated the possible effects KDM3B-ETF1 fusion gene had on breast cancer cell metastasis, invasion and its downstream signaling mediators as revealed from RNA sequence data analysis.
[Cancer Gene Therapy]
Hu, A., Hong, F., Li, D., Xie, Q., Chen, K., Zhu, L., & He, H. (2021). KDM3B-ETF1 fusion gene downregulates LMO2 via the WNT/β-catenin signaling pathway, promoting metastasis of invasive ductal carcinoma. Cancer Gene Therapy, 1–10. https://doi.org/10.1038/s41417-021-00301-z Cite
Abstract
Bookmark

No account yet? Register

0
Share

Vangl2 Promotes the Formation of Long Cytonemes to Enable Distant Wnt/β-Catenin Signaling

Scientists showed that the planar cell polarity protein Vangl2 regulated the distribution of Wnt by cytonemes. They used an organoid formation assay to analyze the requirement for VANGL-dependent WNT cytonemes.
[Nature Communications]
Brunt, L., Greicius, G., Rogers, S., Evans, B. D., Virshup, D. M., Wedgwood, K. C. A., & Scholpp, S. (2021). Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling. Nature Communications, 12(1), 2058. https://doi.org/10.1038/s41467-021-22393-9 Cite
Full Article
Bookmark

No account yet? Register

0
Share

ADCK1 Activates the β-Catenin/TCF Signaling Pathway to Promote the Growth and Migration of Colon Cancer Cells

Researchers found an increase in ADCK1 (AarF domain-containing kinase 1) expression in clinical specimens of colon cancer and animal models. Downregulation of ADCK1 expression inhibited the colony formation and infiltration of cancer cells, in vivo tumorigenesis, migration, and organoid formation.
[Cell Death & Disease]
Ji, Y., Liu, Y., Sun, C., Yu, L., Wang, Z., Du, X., Yang, W., Zhang, C., Tao, C., Wang, J., Yang, X., Di, S., & Huang, Y. (2021). ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells. Cell Death & Disease, 12(4), 1–12. https://doi.org/10.1038/s41419-021-03624-9 Cite
Full Article
Bookmark

No account yet? Register

0
Share

HomeoboxC6 Promotes Metastasis by Orchestrating the DKK1/Wnt/β-Catenin Axis in Right-Sided Colon Cancer

Hmeobox C6 was validated to be overexpressed in right-sided colon cancer and associated with poor prognosis.
[Cell Death & Disease]
Qi, L., Chen, J., Zhou, B., Xu, K., Wang, K., Fang, Z., Shao, Y., Yuan, Y., Zheng, S., & Hu, W. (2021). HomeoboxC6 promotes metastasis by orchestrating the DKK1/Wnt/β-catenin axis in right-sided colon cancer. Cell Death & Disease, 12(4), 1–13. https://doi.org/10.1038/s41419-021-03630-x Cite
Full Article
Bookmark

No account yet? Register

0
Share

Endothelial Wnts Control Mammary Epithelial Patterning via Fibroblast Signaling

To enable cell-type-specific gene manipulation in vitro, scientists establish an organoid system via coculture of endothelial cells (ECs), fibroblasts, and mammary epithelial cells.
[Cell Reports]
Wang, J., Song, W., Yang, R., Li, C., Wu, T., Dong, X. B., Zhou, B., Guo, X., Chen, J., Liu, Z., Yu, Q. C., Li, W., Fu, J., & Zeng, Y. A. (2021). Endothelial Wnts control mammary epithelial patterning via fibroblast signaling. Cell Reports, 34(13). https://doi.org/10.1016/j.celrep.2021.108897 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

A Role for Dynlt3 in Melanosome Movement, Distribution, Acidity and Transfer

The level of Dynlt3 is dependent on β-catenin activity, revealing a function of the Wnt/β-catenin signaling pathway during melanocyte and skin pigmentation, by coupling the transport, positioning and acidity of melanosomes required for their transfer.
[Communications Biology]
Aktary, Z., Conde-Perez, A., Rambow, F., Di Marco, M., Amblard, F., Hurbain, I., Raposo, G., Delevoye, C., Coscoy, S., & Larue, L. (2021). A role for Dynlt3 in melanosome movement, distribution, acidity and transfer. Communications Biology, 4(1), 1–15. https://doi.org/10.1038/s42003-021-01917-5 Cite
Full Article
Bookmark

No account yet? Register

0
Share

BCL9/BCL9L Promotes Tumorigenicity through Immune-Dependent and Independent Mechanisms in Triple Negative Breast Cancer

Investigators demonstrated that the expression of BCL9 and BCL9L was directly correlated with malignancy in TNBC patient tumors and that BCL9 and BCL9L promoted tumor cell growth, cell migration and metastasis in TNBC models.
[Oncogene]
Wang, X., Feng, M., Xiao, T., Guo, B., Liu, D., Liu, C., Pei, J., Liu, Q., Xiao, Y., Rosin-Arbesfeld, R., Shi, Y., Zhou, Y., Yang, M., Feng, Y.-X., Jiang, Y., Shao, Z., Yu, K., & Zhu, D. (2021). BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01756-y Cite
Abstract
Bookmark

No account yet? Register

0
Share
Share