APC Loss Induces Warburg Effect via Increased PKM2 Transcription in Colorectal Cancer

The effects of APC-loss or Wnt ligand on the identified enzymes, PKM2 and LDHA, as well as Warburg effects were investigated. A linkage between activation of Wnt/β-catenin signalling and cancer metabolism was analysed in tumour of Apcmin/+ mice and CRC patients. The roles of PKM2 in cancer metabolism, which depends on Wnt/β-catenin signalling, were assessed in xenograft-tumours.
[British Journal of Cancer]
APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer | British Journal of Cancer. (n.d.). Retrieved October 19, 2020, from https://www.nature.com/articles/s41416-020-01118-7 Cite
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LncRNA SNHG10 Promotes the Proliferation and Invasion of Osteosarcoma via Wnt/β-Catenin Signaling

In vitro experiments (including colony formation, CCK-8, wound healing and transwell assays) and in vivo experiments indicated that down-regulation of SNHG10 significantly suppressed the proliferation and invasion of osteosarcoma cells
[Molecular Therapy-Nucleic Acids]
Zhu, S., Liu, Y., Wang, X., Wang, J., & Xi, G. (2020). LncRNA SNHG10 promotes the proliferation and invasion of osteosarcoma via Wnt/β-catenin signaling. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.10.010 Cite
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LncRNA SNHG11 Promotes Gastric Cancer Progression by Activating Wnt/β-Catenin Pathway and Oncogenic Autophagy

Long non-coding RNA small nucleolar host gene 11 (SNHG11) post-transcriptionally upregulated catenin beta 1 and autophagy related 12 through miR-483-3p/miR-1276, while the processing of pre-miR-483/pre-miR-1276 was hindered by SNHG11. SNHG11 induced GSK-3β ubiquitination through interacting with Cullin 4A to further activate the Wnt/β-catenin pathway.
[Molecular Therapy]
LncRNA SNHG11 promotes gastric cancer progression by activating Wnt/β-catenin pathway and oncogenic autophagy: Molecular Therapy. (n.d.). Retrieved October 15, 2020, from https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(20)30545-1 Cite
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Cir-ITCH Inhibits Gastric Cancer Migration, Invasion and Proliferation by Regulating the Wnt/β-Catenin Pathway

cir-ITCH was shown to prevent gastric cancer tumourgenesis through the Wnt/β-catenin signalling pathway by sequestering miR-17.
[Scientific Reports]
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Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling

Researchers showed that volumetric compression regulated the growth of intestinal organoids by modifying intracellular crowding and elevating Wnt/β-catenin signaling.
[Cell Stem Cell]
Li, Y., Chen, M., Hu, J., Sheng, R., Lin, Q., He, X., & Guo, M. (2020). Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.09.012 Cite
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Small GTPase RAB6 Deficiency Promotes Alveolar Progenitor Cell Renewal and Attenuates PM2.5-Induced Lung Injury and Fibrosis

Investigators demonstrated that knockout of RAB6 inhibited pulmonary fibrosis, oxidative stress, and type 2 alveolar epithelial cells (AEC2) cell death in fine particulate matter (PM2.5)-injured mice. In addition, knockout of RAB6 decreased Dickkopf 1 autocrine and activated proliferation, self-renewal, and wnt/β-catenin signaling of PM2.5-injured AEC2 cells.
[Cell Death & Disease]
Yang, L., Liu, G., Li, X., Xia, Z., Wang, Y., Lin, W., Zhang, W., Zhang, W., & Li, X. (2020). Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis. Cell Death & Disease, 11(10), 1–17. https://doi.org/10.1038/s41419-020-03027-2 Cite
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Critical Role of HOX Transcript Antisense Intergenic RNA (HOTAIR) in Gliomas

The authors provide evidence on the functional role of HOX transcript antisense intergenic RNA (HOTAIR) in gliomas and discuss the benefits of its targeting as a novel approach toward glioma treatment.
[Journal of Molecular Medicine-Jmm]
Angelopoulou, E., Paudel, Y. N., & Piperi, C. (2020). Critical role of HOX transcript antisense intergenic RNA (HOTAIR) in gliomas. Journal of Molecular Medicine. https://doi.org/10.1007/s00109-020-01984-x Cite
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Overexpressed sFRP3 Exerts an Inhibitory Effect on Hepatocellular Carcinoma via Inactivation of the Wnt/β-Catenin Signaling Pathway

Researchers investigated the possible regulatory effects of a secreted frizzled-related protein (sFRP3) on the Wnt/β-catenin signaling pathway and their interactions in hepatocellular carcinoma occurrence.
[Cancer Gene Therapy]
Fang, L., Gao, C., Bai, R.-X., Wang, H.-F., & Du, S.-Y. (2020). Overexpressed sFRP3 exerts an inhibitory effect on hepatocellular carcinoma via inactivation of the Wnt/β-catenin signaling pathway. Cancer Gene Therapy, 1–17. https://doi.org/10.1038/s41417-020-0201-z Cite
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Inhibition of Protein Tyrosine Phosphatase Receptor Type F Suppresses Wnt Signaling in Colorectal Cancer

Scientists investigated the role of protein tyrosine phosphatase receptor type F (PTPRF), a receptor-type tyrosine phosphatase, in regulating Wnt signaling in colorectal cancer. Knockdown of PTPRF decreased cell proliferation in patient-derived primary colon cancer cells and established colorectal cancer cell lines.
[Oncogene]
Gan, T., Stevens, A. T., Xiong, X., Wen, Y.-A., Farmer, T. N., Li, A. T., Stevens, P. D., Golshani, S., Weiss, H. L., Mark Evers, B., & Gao, T. (2020). Inhibition of protein tyrosine phosphatase receptor type F suppresses Wnt signaling in colorectal cancer. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01472-z Cite
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Inhibition of Protein Tyrosine Phosphatase Receptor Type F Suppresses Wnt Signaling in Colorectal Cancer

The rate of proliferation as well as colony formation ability were significantly decreased in tumor organoids grown in 3D, whereas the number of differentiated tumor organoids were markedly increased.
[Oncogene]
Gan, T., Stevens, A. T., Xiong, X., Wen, Y.-A., Farmer, T. N., Li, A. T., Stevens, P. D., Golshani, S., Weiss, H. L., Mark Evers, B., & Gao, T. (2020). Inhibition of protein tyrosine phosphatase receptor type F suppresses Wnt signaling in colorectal cancer. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01472-z Cite
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The Innate Immune Effector ISG12a Promotes Cancer Immunity by Suppressing the Canonical Wnt/β-Catenin Signaling Pathway

ISG12a was found to be expressed at low levels in gastrointestinal cancer, represented by hepatocellular cancer and gastric cancer, and identified as a tumor suppressor that affects clinical prognosis.
[Cellular & Molecular Immunology]
Deng, R., Zuo, C., Li, Y., Xue, B., Xun, Z., Guo, Y., Wang, X., Xu, Y., Tian, R., Chen, S., Liu, Q., Chen, J., Wang, J., Huang, X., Li, H., Guo, M., Wang, X., Yang, M., Wu, Z., … Zhu, H. (2020). The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway. Cellular & Molecular Immunology, 1–17. https://doi.org/10.1038/s41423-020-00549-9 Cite
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