Circular RNA stabilizing HOXC10 (cis-HOX) was robustly expressed in colorectal tumor-initiating cells (TICs). cis-HOX knockout decreased colorectal TIC numbers and impaired the self-renewal, tumorigenesis, and metastatic capacities of TICs, whereas cis-HOX overexpression drove colorectal TIC self-renewal and metastasis.
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The relevance of pleckstrin homology-like domain family A, member 3 (PHLDA3) in prostate cancer has not been explored. Scientists illustrated the possible roles and mechanisms of PHLDA3 in prostate cancer.
[Biochemical and Biophysical Research Communications]
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Scientists investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms.
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The authors suggest that proteomic profiles at the early stage of chronic lymphocytic leukemia (CLL) can discriminate progressive from stable disease and that RNA splicing dysregulation underlies CLL evolution, which opens new perspectives in terms of biomarkers and therapy.
[Journal of Leukocyte Biology]
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Researchers investigated how ICG001 could prevent cardiac hypertrophy and fibrosis induced by transverse aortic constriction and found it may have mediated the substrates in the glycolysis pathway and the distinct alteration of oxidative stress during cardiac hypertrophy and heart failure.
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Researchers identified a common molecular event which would provide a novel prognostic biomarker and therapeutic target for hepatocellular carcinoma.
[British Journal of Cancer]
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Investigators developed a patient-derived colorectal cancer organoid model and performed pairwise analysis of 87 CCOs and their matched primary tumors. The tumor immune microenvironment type of the primary tumor was classified as immuno-active, immuno-exhausted, or immuno-desert.
[Journal of Experimental & Clinical Cancer Research]
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Cho, E. J., Kim, M., Jo, D., Kim, J., Oh, J.-H., Chung, H. C., Lee, S., Kim, D., Chun, S.-M., Kim, J., Lee, H., Kim, T. W., Yu, C. S., Sung, C. O., & Jang, S. J. (2021). Immuno-genomic classification of colorectal cancer organoids reveals cancer cells with intrinsic immunogenic properties associated with patient survival. Journal of Experimental & Clinical Cancer Research, 40(1), 230. https://doi.org/10.1186/s13046-021-02034-1 Cite
Exosome marker protein levels were increased in the exosomes derived from human umbilical cord MSCs (hUMSC-Ex) compared with those in hUMSC suspension, indicating that exosomes were successfully isolated from hUMSCs.
[Acta Biochimica et Biophysica Sinica]
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Gao, H., Yu, Z., Li, Y., & Wang, X. (2021). miR-100-5p in human umbilical cord mesenchymal stem cell–derived exosomes mediates eosinophilic inflammation to alleviate atherosclerosis via the FZD5/Wnt/β-catenin pathway. Acta Biochimica et Biophysica Sinica, gmab093. https://doi.org/10.1093/abbs/gmab093 Cite
Long non-coding RNAs and miRs are differentially expressed in ovarian cancer (OC) cells and influence OC progression. Investigators explored the underlying roles of LINC00115 and miR-30a in OC.
[Cancer Cell International]
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Researchers investigated the molecular mechanism whereby Stat3 regulates skeletal development and osteoblast differentiation.
[Proceedings of the National Academy of Sciences of the United States of America]
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Topical application of UFP-512 increased the hair length in hair organ cultures and promoted the proliferation and the migration of outer root sheath cells.
[Biomolecules & therapeutics]