Identification of Cis-HOX-HOXC10 Axis as a Therapeutic Target for Colorectal Tumor-Initiating Cells without APC Mutations

Circular RNA stabilizing HOXC10 (cis-HOX) was robustly expressed in colorectal tumor-initiating cells (TICs). cis-HOX knockout decreased colorectal TIC numbers and impaired the self-renewal, tumorigenesis, and metastatic capacities of TICs, whereas cis-HOX overexpression drove colorectal TIC self-renewal and metastasis.
[Cell Reports]
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PHLDA3 Exerts an Antitumor Function in Prostate Cancer by Down-Regulating Wnt/β-Catenin Pathway via Inhibition of Akt

The relevance of pleckstrin homology-like domain family A, member 3 (PHLDA3) in prostate cancer has not been explored. Scientists illustrated the possible roles and mechanisms of PHLDA3 in prostate cancer.
[Biochemical and Biophysical Research Communications]
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VALD-3, a Schiff Base Ligand Synthesized from O-Vanillin Derivatives, Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Cells by Inhibiting the Wnt/β-Catenin Pathway

Scientists investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms.
[Scientific Reports]
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Identification of Altered Cell Signaling Pathways Using Proteomic Profiling in Stable and Progressive Chronic Lymphocytic Leukemia

The authors suggest that proteomic profiles at the early stage of chronic lymphocytic leukemia (CLL) can discriminate progressive from stable disease and that RNA splicing dysregulation underlies CLL evolution, which opens new perspectives in terms of biomarkers and therapy.
[Journal of Leukocyte Biology]
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Inhibition of the Canonical Wnt Signaling Pathway by a β-Catenin/CBP Inhibitor Prevents Heart Failure by Ameliorating Cardiac Hypertrophy and Fibrosis

Researchers investigated how ICG001 could prevent cardiac hypertrophy and fibrosis induced by transverse aortic constriction and found it may have mediated the substrates in the glycolysis pathway and the distinct alteration of oxidative stress during cardiac hypertrophy and heart failure.
[Scientific Reports]
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SLC38A4 Functions as a Tumour Suppressor in Hepatocellular Carcinoma through Modulating Wnt/β-Catenin/MYC/HMGCS2 Axis

Researchers identified a common molecular event which would provide a novel prognostic biomarker and therapeutic target for hepatocellular carcinoma.
[British Journal of Cancer]
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Immuno-Genomic Classification of Colorectal Cancer Organoids Reveals Cancer Cells with Intrinsic Immunogenic Properties Associated with Patient Survival

Investigators developed a patient-derived colorectal cancer organoid model and performed pairwise analysis of 87 CCOs and their matched primary tumors. The tumor immune microenvironment type of the primary tumor was classified as immuno-active, immuno-exhausted, or immuno-desert.
[Journal of Experimental & Clinical Cancer Research]
Cho, E. J., Kim, M., Jo, D., Kim, J., Oh, J.-H., Chung, H. C., Lee, S., Kim, D., Chun, S.-M., Kim, J., Lee, H., Kim, T. W., Yu, C. S., Sung, C. O., & Jang, S. J. (2021). Immuno-genomic classification of colorectal cancer organoids reveals cancer cells with intrinsic immunogenic properties associated with patient survival. Journal of Experimental & Clinical Cancer Research, 40(1), 230. https://doi.org/10.1186/s13046-021-02034-1 Cite
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miR-100-5p in Human Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Mediates Eosinophilic Inflammation to Alleviate Atherosclerosis via the FZD5/Wnt/β-Catenin Pathway

Exosome marker protein levels were increased in the exosomes derived from human umbilical cord MSCs (hUMSC-Ex) compared with those in hUMSC suspension, indicating that exosomes were successfully isolated from hUMSCs.
[Acta Biochimica et Biophysica Sinica]
Gao, H., Yu, Z., Li, Y., & Wang, X. (2021). miR-100-5p in human umbilical cord mesenchymal stem cell–derived exosomes mediates eosinophilic inflammation to alleviate atherosclerosis via the FZD5/Wnt/β-catenin pathway. Acta Biochimica et Biophysica Sinica, gmab093. https://doi.org/10.1093/abbs/gmab093 Cite
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LINC00115 Promotes Stemness and Inhibits Apoptosis of Ovarian Cancer Stem Cells by Upregulating SOX9 and Inhibiting the Wnt/β-Catenin Pathway through Competitively Binding to microRNA-30a

Long non-coding RNAs and miRs are differentially expressed in ovarian cancer (OC) cells and influence OC progression. Investigators explored the underlying roles of LINC00115 and miR-30a in OC.
[Cancer Cell International]
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Stat3 Loss in Mesenchymal Progenitors Causes Job Syndrome-Like Skeletal Defects by Reducing Wnt/β-Catenin Signaling

Researchers investigated the molecular mechanism whereby Stat3 regulates skeletal development and osteoblast differentiation.
[Proceedings of the National Academy of Sciences of the United States of America]
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Hair Growth Promotion by δ-Opioid Receptor Activation

Topical application of UFP-512 increased the hair length in hair organ cultures and promoted the proliferation and the migration of outer root sheath cells.
[Biomolecules & therapeutics]
Zheng, M., Choi, N., Balboni, G., Xia, Y., & Sung, J.-H. (n.d.). Hair Growth Promotion by δ-Opioid Receptor Activation. Biomolecules & Therapeutics. https://doi.org/10.4062/biomolther.2021.064 Cite
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