Acute Multidrug Delivery via a Wearable Bioreactor Facilitates Long-Term Limb Regeneration and Functional Recovery in Adult Xenopus laevis

Researchers demonstrated long-term regrowth, marked tissue repatterning, and functional restoration of an amputated Xenopus laevis hindlimb following a 24-hour exposure to a multidrug, pro-regenerative treatment delivered by a wearable bioreactor.
[Science Advances]
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Whole-Genome Sequencing Reveals the Evolutionary Trajectory of HBV-Related Hepatocellular Carcinoma Early Recurrence

Investigators performed whole-genome sequencing on 40 pairs of primary and early-recurrent hepatitis B virus (HBV)-related hepatocellular carcinoma tumors from patients who received curative resection, and from four patients whose primary and recurrent tumor were extensively sampled.
[Signal Transduction and Targeted Therapy]
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Wnt/β-Catenin Signaling in Colorectal Cancer: Is Therapeutic Targeting Even Possible?

The authors reviewed the recent progress of this signal transduction pathway in colorectal tumorigenesis.
[Biochimie]
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Long Non-Coding RNA TPT1-AS1 Suppresses APC Transcription in a STAT1-Dependent Manner to Increase the Stemness of Colorectal Cancer Stem Cells

Stem cells from colorectal cancer HCT116 and CACO2 cells were isolated. TPT1-AS1 was significantly highly expressed in the CSCs compared to non-stem cells.
[Molecular Biotechnology]
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Hypoxia-Inducible Factor 1α Induces Osteo/Odontoblast Differentiation of Human Dental Pulp Stem Cells via Wnt/β-Catenin Transcriptional Cofactor BCL9

The authors examined the role of B-cell CLL/lymphoma 9 (BCL9), which is downstream of hypoxia-inducible factor 1α and a Wnt/β-catenin transcriptional cofactor, in the osteo/odontoblastic differentiation of human dental pulp stem cells under hypoxic conditions.
[Scientific Reports]
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Role, Molecular Mechanism and the Potential Target of Breast Cancer Stem Cells in Breast Cancer Development

Scientists discuss the latest developments in breast cancer stem cells (BCSCs) research, focusing on the analysis of specific markers, critical signaling pathways that maintain the stemness of BCSCs, such as NOTCH, Wnt/β-catenin, STAT3, Hedgehog, and Hippo-YAP signaling.
[Biomedicine & Pharmacotherapy]
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β-Catenin Perturbations Control Differentiation Programs in Mouse Embryonic Stem Cells

By applying an in vitro system enabling inducible gene expression control, investigators reported that moderate induction of transcriptionally active exogenous β-catenin in β-catenin null mouse ESCs promoted epiblast-like cell derivation in vitro.
[iScience]
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Fibrinogen Improves Liver Function via Promoting Cell Aggregation and Fibronectin Assembly in Hepatic Spheroids

Human primary hepatocyte organoids and HepaRG spheroids showed more mature hepatocyte phenotype after adding fibronectin and fibrinogen to the culture system.
[Biomaterials]
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Downregulation of SFRP2 Facilitates Cancer Stemness and Radioresistance of Glioma Cells via Activating Wnt/β-Catenin Signaling

Researchers found that secreted frizzled-related protein 2 (SFRP2) was downregulated in radiotherapy-treated glioma patients, and low SFRP2 expression was correlated with advanced tumor stage and poor prognosis.
[PLoS One]
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TAZ Exhibits Phase Separation Properties and Interacts with Smad7 and β-Catenin to Repress Skeletal Myogenesis

Researchers assessed a potential role of TAZ on theSmad7/β-catenin complex in muscle cells. They documented functional interactions between Smad7, TAZ and β-catenin in myogenic cells.
[Journal of Cell Science]
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Loss of DSTYK Activates Wnt/β-Catenin Signaling and Glycolysis in Lung Adenocarcinoma

Researchers showed that the loss of dual serine/threonine tyrosine protein kinase led to the activation of Wnt/β-catenin signaling and upregulation of its target gene, lactate dehydrogenase, and thus the elevation of lactate.
[Cell Death & Disease]
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