Doxycycline Restores the Impaired Osteogenic Commitment of Diabetic-Derived Bone Marrow Mesenchymal Stromal Cells by Increasing the Canonical WNT Signaling

Researchers aimed to address the modulatory capability and associated molecular signaling of a low dosage doxycycline – a semi-synthetic tetracycline, in the functional activity of osteoblastic progenitor cells, established from a translational diabetic experimental model.
[Molecular and Cellular Endocrinology]
Gomes, P. S., Resende, M., & Fernandes, M. H. (2020). Doxycycline restores the impaired osteogenic commitment of diabetic-derived bone marrow mesenchymal stromal cells by increasing the canonical WNT signaling. Molecular and Cellular Endocrinology, 110975. https://doi.org/10.1016/j.mce.2020.110975 Cite
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ERK/MAPK Signaling Is Essential for Intestinal Development through Wnt Pathway Modulation

Scientists found that deletion of Erk1/2 in intestinal epithelial cells at embryonic stages resulted in an unexpected increase in cell proliferation and migration, expansion of intestinal stem cells and formation of polyp-like structures, leading to postnatal death.
[Development]
ERK/MAPK signaling is essential for intestinal development through Wnt pathway modulation | Development. (n.d.). Retrieved August 7, 2020, from https://dev.biologists.org/content/early/2020/07/30/dev.185678 Cite
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DOCK6 Promotes Chemo- and Radioresistance of Gastric Cancer by Modulating WNT/β-Catenin Signaling and Cancer Stem Cell Traits

The authors identified DOCK6, a guanine nucleotide exchange factor for Rac1 and CDC42, as an independent biomarker for gastric cancer prognosis. Clinical findings indicate the positive correlation of higher DOCK6 expression with tumor size, depth of invasion, lymph node metastasis, vascular invasion, and pathological stage.
[Oncogene]
Chi, H.-C., Tsai, C.-Y., Wang, C.-S., Yang, H.-Y., Lo, C.-H., Wang, W.-J., Lee, K.-F., Lai, L.-Y., Hong, J.-H., Chang, Y.-F., Tsai, M.-M., Yeh, C.-T., Wu, C. H., Hsieh, C.-C., Wang, L.-H., Chen, W.-J., & Lin, K.-H. (2020). DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits. Oncogene, 1–17. https://doi.org/10.1038/s41388-020-01390-0 Cite
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Roniciclib Down-Regulates Stemness and Inhibits Cell Growth by Inducing Nucleolar Stress in Neuroblastoma

Scientists found that neurospheres derived from neuroblastoma stem-like cells showed a homogeneous staining for several key nucleolar proteins, such as Nucleolin, Nucleophosmin-1, Glypican-2 and PES-1.
[Scientific Reports]
Ognibene, M., & Pezzolo, A. (2020). Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma. Scientific Reports, 10(1), 12902. https://doi.org/10.1038/s41598-020-69499-6 Cite
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Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging

Using transgenic mice and pharmacologic studies, the authors found that Wnt/β-catenin within airway basal stem cells was essential for proliferation post-injury in vivo.
[Cell Stem Cell]
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Rapamycin Promotes Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells in a Stage-Dependent Manner

How rapamycin affects cardiomyocyte differentiation of induced pluripotent stem cells is still not fully understood. The authors investigated the effect of rapamycin on cardiomyocyte differentiation based on the embryoid body method.
[Stem Cells and Development]
Jiang, M., Liu, T., Zhang, J., Gao, S., Tao, B., Cao, R., Qiu, Y., Liu, J., Li, Y., Wang, Y., & Cao, F. (2020). Rapamycin Promotes Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells in a Stage-Dependent Manner. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0025 Cite
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Piperine Suppresses the Wnt/β-Catenin Pathway and Has Anti-Cancer Effects on Colorectal Cancer Cells

By using Wnt/β-catenin pathway epistasis experiment scientists showed that piperine inhibited the canonical Wnt pathway induced by overexpression of β-catenin, β-catenin S33A or dnTCF4 VP16, while also suppressing β-catenin nuclear localization in HCT116 cell line.
[Scientific Reports]
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Deacetylation by SIRT1 Promotes the Tumor-Suppressive Activity of HINT1 by Enhancing Its Binding Capacity for β-Catenin or MITF in Colon Cancer and Melanoma Cells

This study revealed an acetylation-dependent regulatory mechanism that governed the tumor-suppressive function of HINT1.
[Experimental and Molecular Medicine]
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