Wnt/β-catenin

[Science] In a model of genetically driven closure of choroid plexus endothelial cells, the authors observed a deficit in short-term memory and anxiety-like behavior, suggesting that choroid plexus closure may have correlated with mental deficits.

[Cell Death & Disease] Scientists evaluated the function of golgi phosphoprotein 3 (GOLPH3) in non-small-cell lung cancer (NSCLC) distal metastasis. GOLPH3 was expressed at high levels in samples from patients with NSCLC and was positively associated with clinicopathologic characteristics including clinical stage classification.

[Journal of Cellular Physiology] LINC00662 can reduce the promoter methylation level of s-adenosylmethionine-dependent hepatocellular carcinoma-promoting genes by regulating the MAT1A/SAM and AHCY/SAH axes, thereby promoting the activation of oncogenes. Scientists summarize the molecular regulation mechanism of LINC00662.

[BMC Cancer] Researchers determined the anticancer effects of a combination of bortezomib and mitoxantrone by apoptosis and proliferation assay in vivo and in vitro.

[Journal of Experimental & Clinical Cancer Research] Researchers found that SETD1A positively regulated the Wnt/β-catenin pathway via interacting with and stabilizing β-catenin.

[Cell Death Discovery] Investigators found that pyrvinium pamoate (PP) and Temozolomide (TMZ) had synergistic effect on inhibiting the viability of glioblastoma multiforme (GBM) cells, and PP induced inhibition of MGMT and enhanced the TMZ chemosensitivity of GBM cells through down-regulating Wnt/β-catenin pathway.