xenograft models

[iScience] The authors investigated the anti-cancer activity of the mitochondrial complex I inhibitor intervenolin, which modulated the tumor microenvironment independent of energy depletion.

[Cell Death & Disease] Scientists performed the first drug repurposing screen to identify compounds that confer synthetic lethality with LIM domains containing 1 (LIMD1) loss in NSCLC cells.

[Ebiomedicine] The authors used the androgen receptor positive CRPC model PC346C-DCC-K to assess the in vitro and in vivo activity of combining enzalutamide with cabazitaxel.

[Gastric Cancer] SHG assays with mouse xenograft models and human samples demonstrated cancer-associated fibroblasts-derived hyaluronan and proteoglycan link protein 1 (HAPLN1) increased tumour invasiveness through ECM remodeling.

[Leukemia] Researchers used cellular, mouse, and humanized models of RAC-dependent BCR-ABL1-driven and Ph-like acute lymphoblastic leukemia to identify VAV3, a tyrosine phosphorylation–dependent RAC guanine nucleotide exchange factor (RacGEF), as the target of the small molecule IODVA1.

[Oncogene] Scientists analyzed clonal dynamics in subclonal population mixtures and used DNA barcode technology that revealed selection for distinct clonal populations in different in vitro and in vivo environmental contexts.