xenograft models

[Oncogene] Investigators generated gene knockouts through genome editing, performed RNA interference-mediated knockdown of gene expression, and ectopically expressed CHRNB2 in gastric cancer cells.

[Molecular Oncology] Researchers showed that VprBP was overexpressed in colon cancer and directly contributed to epigenetic gene silencing and cancer pathogenesis. Mechanistically, the observed function of VprBP was mediated through H2AT120 phosphorylation-driven transcriptional repression of growth regulatory genes, resulting in a significantly higher proliferative capacity of colon cancer cells.

[Cancer Research] Scientists interrogated the regulation of RE1-silencing transcription factor, a transcriptional repressor of neuronal genes, and elucidated molecular programs driving amphicrine prostate cancer and neuroendocrine prostate cancer biology.

[Oncogene] In vitro experiments showed that a subset of combination therapy melanoma cells was sensitive to mTORC1 inhibition.

[Science Advances] Scientists demonstrated that NAD+ metabolism enabled acute myeloid leukemia (AML) to evade apoptosis. They integrated whole-genome CRISPR screening and pan-cancer genetic dependency mapping to identify NAMPT and NMNAT1 as AML dependencies governing NAD+ biosynthesis.

[Biomaterials Science] c-Met-targeted near-infrared fluorescent probe for real-time visualization and dissection of pancreatic ductal adenocarcinoma, and corresponding perineural invasion and lymph node metastasis lesions.