VprBP Directs Epigenetic Gene Silencing through Histone H2A Phosphorylation in Colon Cancer

Researchers showed that VprBP was overexpressed in colon cancer and directly contributed to epigenetic gene silencing and cancer pathogenesis. Mechanistically, the observed function of VprBP was mediated through H2AT120 phosphorylation-driven transcriptional repression of growth regulatory genes, resulting in a significantly higher proliferative capacity of colon cancer cells.