Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsThe authors focus on some recent advances in understanding endothelial cell behavior in health and disease and identify novel molecular players and concepts that could eventually be considered for therapeutic targeting.
[Circulation Research]
6445212 XGXWXXVG items 1 apa 0 default asc 1 151428 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-153c352c3e522490f42d62d3fb71bef3%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22XGXWXXVG%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Eelen%20Guy%20et%20al.%22%2C%22parsedDate%22%3A%222020-07-03%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%202em%3B%20text-indent%3A-2em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EEelen%20Guy%2C%20Treps%20Lucas%2C%20Li%20Xuri%2C%20%26amp%3B%20Carmeliet%20Peter.%20%282020%29.%20Basic%20and%20Therapeutic%20Aspects%20of%20Angiogenesis%20Updated.%20%3Ci%3ECirculation%20Research%3C%5C%2Fi%3E%2C%20%3Ci%3E127%3C%5C%2Fi%3E%282%29%2C%20310%26%23x2013%3B329.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1161%5C%2FCIRCRESAHA.120.316851%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1161%5C%2FCIRCRESAHA.120.316851%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DXGXWXXVG%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Basic%20and%20Therapeutic%20Aspects%20of%20Angiogenesis%20Updated%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Eelen%20Guy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Treps%20Lucas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Li%20Xuri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Carmeliet%20Peter%22%7D%5D%2C%22abstractNote%22%3A%22All%20organisms%20growing%20beyond%20the%20oxygen%20diffusion%20limit%20critically%20depend%20on%20a%20functional%20vasculature%20for%20survival.%20Yet%20blood%20vessels%20are%20far%20more%20than%20passive%2C%20uniform%20conduits%20for%20oxygen%20and%20nutrient%20supply.%20A%20remarkable%20organotypic%20heterogeneity%20is%20brought%20about%20by%20tissue-specific%20differentiated%20endothelial%20cells%20%28lining%20the%20blood%20vessels%5Cu2019%20lumen%29%20and%20allows%20blood%20vessels%20to%20deal%20with%20organ-specific%20demands%20for%20homeostasis.%20On%20the%20flip%20side%2C%20when%20blood%20vessels%20go%20awry%2C%20they%20promote%20life-threatening%20diseases%20characterized%20by%20endothelial%20cells%20inappropriately%20adopting%20an%20angiogenic%20state%20%28eg%2C%20tumor%20vascularization%29%20or%20becoming%20dysfunctional%20%28eg%2C%20diabetic%20microvasculopathies%29%2C%20calling%20respectively%20for%20antiangiogenic%20therapies%20and%20proangiogenic%5C%2Fvascular%20regenerative%20strategies.%20In%20solid%20tumors%2C%20despite%20initial%20enthusiasm%2C%20growth%20factor%5Cu2013based%20%28mostly%20anti-VEGF%20%5Bvascular%20endothelial%20growth%20factor%5D%29%20antiangiogenic%20therapies%20do%20not%20sufficiently%20live%20up%20to%20the%20expectations%20in%20terms%20of%20efficiency%20and%20patient%20survival%2C%20in%20part%2C%20due%20to%20intrinsic%20and%20acquired%20therapy%20resistance.%20Tumors%20cunningly%20deploy%20alternative%20growth%20factors%20than%20the%20ones%20targeted%20by%20the%20antiangiogenic%20therapies%20to%20reinstigate%20angiogenesis%20or%20revert%20to%20other%20ways%20of%20securing%20blood%20flow%2C%20independently%20of%20the%20targeted%20growth%20factors.%20In%20trying%20to%20alleviate%20tissue%20ischemia%20and%20to%20repair%20dysfunctional%20or%20damaged%20endothelium%2C%20local%20in-tissue%20administration%20of%20%28genes%20encoding%29%20proangiogenic%20factors%20or%20endothelial%20%28stem%29%20cells%20harnessing%20regenerative%20potential%20have%20been%20explored.%20Notwithstanding%20evaluation%20in%20clinical%20trials%2C%20these%20approaches%20are%20often%20hampered%20by%20dosing%20issues%20and%20limited%20half-life%20or%20local%20retention%20of%20the%20administered%20agents.%20Here%2C%20without%20intending%20to%20provide%20an%20all-encompassing%20historical%20overview%2C%20we%20focus%20on%20some%20recent%20advances%20in%20understanding%20endothelial%20cell%20behavior%20in%20health%20and%20disease%20and%20identify%20novel%20molecular%20players%20and%20concepts%20that%20could%20eventually%20be%20considered%20for%20therapeutic%20targeting.%22%2C%22date%22%3A%22July%203%2C%202020%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1161%5C%2FCIRCRESAHA.120.316851%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ahajournals.org%5C%2Fdoi%5C%2F10.1161%5C%2FCIRCRESAHA.120.316851%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-07-03T21%3A33%3A02Z%22%7D%7D%5D%7D
Eelen Guy, Treps Lucas, Li Xuri, & Carmeliet Peter. (2020). Basic and Therapeutic Aspects of Angiogenesis Updated. Circulation Research, 127(2), 310–329. https://doi.org/10.1161/CIRCRESAHA.120.316851 Cite
