Monocytes from Infliximab-Resistant Patients with Crohn’s Disease Exhibit a Disordered Cytokine Profile

Investigators compared the inflammatory phenotype of monocytes from Crohn’s disease patients, who responded or non-responded to infliximab. Under basal conditions, the mRNA for the cytokines TNFα, IL-23, IL-1β and the chemokines CXCL8/IL-8, CCL5/RANTES and CCL2/MCP-1 was up-regulated in monocytes from non-responders than responders.